Literature DB >> 17371246

Physiological roles of PKB/Akt isoforms in development and disease.

B Dummler1, B A Hemmings.   

Abstract

PKB (protein kinase B, also known as Akt) is a serine/threonine protein kinase that is important in various signalling cascades and acts as a major signal transducer downstream of activated phosphoinositide 3-kinase. There are three closely related isoforms of PKB in mammalian cells, PKBalpha (Akt1), PKBbeta (Akt2) and PKBgamma (Akt3), and this review discusses recent advances in our understanding of the functions of these isoforms in the regulation of adipocyte differentiation, glucose homoeostasis and tumour development.

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Year:  2007        PMID： 17371246     DOI： 10.1042/BST0350231

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  140 in total

1.  PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.

Authors:  Qiuting Feng; Ruomin Di; Fang Tao; Zai Chang; Shuangshuang Lu; Wenjing Fan; Congjia Shan; Xinli Li; Zhongzhou Yang
Journal:  Mol Cell Biol       Date:  2010-05-10       Impact factor: 4.272

Review 2.  Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape.

Authors:  Margrith E Mattmann; Sydney L Stoops; Craig W Lindsley
Journal:  Expert Opin Ther Pat       Date:  2011-06-02       Impact factor: 6.674

3.  Oxidation of Akt2 kinase promotes cell migration and regulates G1-S transition in the cell cycle.

Authors:  Revati Wani; N Sharmila Bharathi; Jeffrey Field; Allen W Tsang; Cristina M Furdui
Journal:  Cell Cycle       Date:  2011-10-01       Impact factor: 4.534

4.  Insulin reveals Akt signaling as a novel regulator of norepinephrine transporter trafficking and norepinephrine homeostasis.

Authors:  Sabrina D Robertson; Heinrich J G Matthies; W Anthony Owens; Vidiya Sathananthan; Nicole S Bibus Christianson; J Phillip Kennedy; Craig W Lindsley; Lynette C Daws; Aurelio Galli
Journal:  J Neurosci       Date:  2010-08-25       Impact factor: 6.167

5.  Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development.

Authors:  Fei Zhou; Zai Chang; Luqing Zhang; Young-Kwon Hong; Bin Shen; Bo Wang; Fan Zhang; Guangming Lu; Denis Tvorogov; Kari Alitalo; Brian A Hemmings; Zhongzhou Yang; Yulong He
Journal:  Am J Pathol       Date:  2010-08-19       Impact factor: 4.307

6.  FKBP5 genetic variation: association with selective serotonin reuptake inhibitor treatment outcomes in major depressive disorder.

Authors:  Katarzyna A Ellsworth; Irene Moon; Bruce W Eckloff; Brooke L Fridley; Gregory D Jenkins; Anthony Batzler; Joanna M Biernacka; Ryan Abo; Abra Brisbin; Yuan Ji; Scott Hebbring; Eric D Wieben; David A Mrazek; Richard M Weinshilboum; Liewei Wang
Journal:  Pharmacogenet Genomics       Date:  2013-03       Impact factor: 2.089

7.  A purified capsular polysaccharide markedly inhibits inflammatory response during endotoxic shock.

Authors:  M Piccioni; C Monari; S Kenno; E Pericolini; E Gabrielli; D Pietrella; S Perito; F Bistoni; T R Kozel; A Vecchiarelli
Journal:  Infect Immun       Date:  2012-10-22       Impact factor: 3.441

Review 8.  AKT/PKB Signaling: Navigating the Network.

Authors:  Brendan D Manning; Alex Toker
Journal:  Cell       Date:  2017-04-20       Impact factor: 41.582

Review 9.  Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging.

Authors:  Vinodkumar B Pillai; Nagalingam R Sundaresan; Mahesh P Gupta
Journal:  Circ Res       Date:  2014-01-17       Impact factor: 17.367

10.  Asymmetric dimethylarginine induces endothelial nitric-oxide synthase mitochondrial redistribution through the nitration-mediated activation of Akt1.

Authors:  Ruslan Rafikov; Olga Rafikova; Saurabh Aggarwal; Christine Gross; Xutong Sun; Julin Desai; David Fulton; Stephen M Black
Journal:  J Biol Chem       Date:  2012-12-19       Impact factor: 5.157
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