Literature DB >> 17368901

1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation.

Robert G Wei1, Marc Adler, David Davey, Elena Ho, Raju Mohan, Mark Polokoff, Jih-Lie Tseng, Marc Whitlow, Wei Xu, Shendong Yuan, Gary Phillips.   

Abstract

A new series of 1-(1,3-benzodioxol-5-ylmethyl)-3-[4-(1H-Imidazol-1-yl)phenoxy]-piperidine analogs were designed and identified as potent and selective inhibitors of NO formation based both on the crystal structure of a murine iNOS Delta114 monomer domain/ inhibitor complex and inhibition of the NO formation in human A172 cell assays. Compound 12S showed high potency and high iNOS selectivity versus nNOS and eNOS.

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Year:  2007        PMID： 17368901     DOI： 10.1016/j.bmcl.2007.02.053

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Crystal structure of catena-poly[[bis-(acetato-κO)copper(II)]-bis-[μ-4-(1H-imidazol-1-yl)phenol]-κ2N3:O;κ2O:N3].

Authors:  Mehmet Poyraz; Musa Sarı
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-01-20

2.  Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors.

Authors:  Guo-Hua Chu; Bertrand Le Bourdonnec; Minghua Gu; Christopher W Ajello; Lara K Leister; Ian Sellitto; Joel A Cassel; Paul A Tuthill; Heather O' Hare; Robert N Dehaven; Roland E Dolle
Journal:  Open Med Chem J       Date:  2009-11-18

3.  Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.

Authors:  Paramita Mukherjee; Huiying Li; Irina Sevrioukova; Georges Chreifi; Pavel Martásek; Linda J Roman; Thomas L Poulos; Richard B Silverman
Journal:  J Med Chem       Date:  2014-12-29       Impact factor: 7.446
  3 in total

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