Chin-Jung Wang1, Chyi-Long Lee, Leung-To Yuen, Nari Kay, Chien-Min Han, Yung-Kuei Soong. 1. Department of Obstetrics and Gynecology, Division of Gynecologic Endoscopy, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Kwei-Shan, Tao-Yuan, Taiwan. wang2260@cgmh.org.tw
Abstract
STUDY OBJECTIVE: To evaluate the influence of oxytocin on operative blood loss during laparoscopic myomectomy (LM). DESIGN: Prospective clinical study (Canadian Task Force classification I). SETTING:Tertiary care university hospital. PATIENTS: Sixty women scheduled for myomectomy because of symptomatic uterine myomas. INTERVENTION: Two ampules of oxytocin (10 u/mL/amp) were added to 1000 mL of saline solution running at the rate of 40 mU/min during the course of LM. MEASUREMENTS AND MAIN RESULTS:Blood loss and blood transfusion rate were significantly greater in the group without oxytocin infusion (group B) than in the group with oxytocin infusion (group A), with 445.0 +/- 268.6 mL (95% CI 344.7-545.3) versus 269.5 +/- 225.8 mL (95% CI 185.2-353.8)/(p <.05), and 36.7% versus 6.7% (p <.05), respectively. There was no significant difference in average age, body weight, or numbers of vaginal delivery and cesarean sections between the 2 groups. There was no significant difference in mean total myoma weight, main myoma size, postoperative stay, and complications between the 2 groups. CONCLUSION:Oxytocin infusion combined with skillful surgical techniques may decrease operative blood loss and blood transfusion during LM.
RCT Entities:
STUDY OBJECTIVE: To evaluate the influence of oxytocin on operative blood loss during laparoscopic myomectomy (LM). DESIGN: Prospective clinical study (Canadian Task Force classification I). SETTING: Tertiary care university hospital. PATIENTS: Sixty women scheduled for myomectomy because of symptomatic uterine myomas. INTERVENTION: Two ampules of oxytocin (10 u/mL/amp) were added to 1000 mL of saline solution running at the rate of 40 mU/min during the course of LM. MEASUREMENTS AND MAIN RESULTS:Blood loss and blood transfusion rate were significantly greater in the group without oxytocin infusion (group B) than in the group with oxytocin infusion (group A), with 445.0 +/- 268.6 mL (95% CI 344.7-545.3) versus 269.5 +/- 225.8 mL (95% CI 185.2-353.8)/(p <.05), and 36.7% versus 6.7% (p <.05), respectively. There was no significant difference in average age, body weight, or numbers of vaginal delivery and cesarean sections between the 2 groups. There was no significant difference in mean total myoma weight, main myoma size, postoperative stay, and complications between the 2 groups. CONCLUSION:Oxytocin infusion combined with skillful surgical techniques may decrease operative blood loss and blood transfusion during LM.