Literature DB >> 17367198

An improved procedure for the three-component synthesis of highly substituted pyridines using ionic liquid.

Brindaban C Ranu1, Ranjan Jana, S Sowmiah.   

Abstract

A basic ionic liquid, [bmIm]OH, efficiently promotes a one-pot, three-component condensation of aldehydes, malononitrile, and thiophenols to produce highly substituted pyridines in high yields at room temperature. This reaction does not involve any hazardous organic solvent and toxic catalyst. The ionic liquid is recovered and recycled for subsequent reactions.

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Year:  2007        PMID： 17367198     DOI： 10.1021/jo070015g

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  7 in total

1.  Nickel-Catalyzed [2+2+2] Cycloaddition of Diynes and Cyanamides.

Authors:  Ryan M Stolley; Michael T Maczka; Janis Louie
Journal:  European J Org Chem       Date:  2011-07

2.  Multi-component synthesis of 2-amino-6-(alkyllthio)pyridine-3,5-dicarbonitriles using Zn(II) and Cd(II) metal-organic frameworks (MOFs) under solvent-free conditions.

Authors:  Muralidhara Thimmaiah; Peng Li; Sridhar Regati; Banglin Chen; John Cong-Gui Zhao
Journal:  Tetrahedron Lett       Date:  2012-09-05       Impact factor: 2.415

Review 3.  2-Amino-3,5-dicarbonitrile-6-sulfanylpyridines: synthesis and multiple biological activity - a review.

Authors:  Nail S Akhmadiev; Vnira R Akhmetova; Askhat G Ibragimov
Journal:  RSC Adv       Date:  2021-03-23       Impact factor: 3.361

4.  The Monte Carlo approach to model and predict the melting point of imidazolium ionic liquids using hybrid optimal descriptors.

Authors:  Shahram Lotfi; Shahin Ahmadi; Parvin Kumar
Journal:  RSC Adv       Date:  2021-10-18       Impact factor: 4.036

5.  Polyfunctional nitriles in organic syntheses: a novel route to aminopyrroles, pyridazines and pyrazolo[3,4-c]pyridazines.

Authors:  Saleh M Al-Mousawi; Moustafa Sherief Moustafa; Herbert Meier; Heinz Kolshorn; Mohamed Hilmy Elnagdi
Journal:  Molecules       Date:  2009-02-16       Impact factor: 4.411

6.  Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors Ranging from Pan Ligands to Combined A1/A2B Partial Agonists.

Authors:  Daniela Catarzi; Flavia Varano; Katia Varani; Fabrizio Vincenzi; Silvia Pasquini; Diego Dal Ben; Rosaria Volpini; Vittoria Colotta
Journal:  Pharmaceuticals (Basel)       Date:  2019-10-22

7.  Facile synthesis and antiproliferative activity of new 3-cyanopyridines.

Authors:  Hassan M Abdel-Aziz; Sobhi M Gomha; Abdelaziz A El-Sayed; Yahia Nasser Mabkhot; Abdulrhman Alsayari; Abdullatif Bin Muhsinah
Journal:  BMC Chem       Date:  2019-12-28
  7 in total

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