Literature DB >> 17366734

Cytotoxic isoquinoline alkaloids from the aerial parts of Corydalis incisa.

Sang Un Choi1, Nam-In Baek, Sung-Hoon Kim, Jae Heon Yang, Jae Soon Eun, Tae Yong Shin, Jong Pil Lim, Jae Hyeok Lee, Hoon Jeon, Mi-Young Yun, Kang-Hyun Leem, Hee Wook Park, Dae Keun Kim.   

Abstract

Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2 and HCT15 tumor cells.

Entities:  

Mesh:

Substances:

Year:  2007        PMID: 17366734     DOI: 10.1007/bf02977687

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN: 0253-6269            Impact factor:   4.946


  4 in total

1.  Preparative isolation of alkaloids from Corydalis bungeana Turcz. by high-speed counter-current chromatography using stepwise elution.

Authors:  Lili Niu; Zhensheng Xie; Tanxi Cai; Peng Wu; Peng Xue; Xiulan Chen; Zhiyong Wu; Yoichiro Ito; Famei Li; Fuquan Yang
Journal:  J Sep Sci       Date:  2011-03-08       Impact factor: 3.645

Review 2.  The Anticancer Effect of Natural Plant Alkaloid Isoquinolines.

Authors:  Dahye Yun; So Young Yoon; Soo Jung Park; Yoon Jung Park
Journal:  Int J Mol Sci       Date:  2021-02-06       Impact factor: 5.923

3.  Metabolism and Bioactivation of Corynoline With Characterization of the Glutathione/Cysteine Conjugate and Evaluation of Its Hepatotoxicity in Mice.

Authors:  Ruijuan Liu; Fang Zhou; He He; Jingyao Wei; Xin Tian; Li Ding
Journal:  Front Pharmacol       Date:  2018-11-06       Impact factor: 5.810

4.  Jatrorrhizine inhibits colorectal carcinoma proliferation and metastasis through Wnt/β-catenin signaling pathway and epithelial-mesenchymal transition.

Authors:  Pan Wang; Xiao-Yan Gao; Si-Qian Yang; Zhi-Xin Sun; Lu-Lu Dian; Muhammad Qasim; Aung Thu Phyo; Zong-Suo Liang; Yan-Fang Sun
Journal:  Drug Des Devel Ther       Date:  2019-07-08       Impact factor: 4.162

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.