| Literature DB >> 17364869 |
Maria Luisa Bondì1, Emanuela Fabiola Craparo, Gaetano Giammona, Melchiorre Cervello, Antonina Azzolina, Patrizia Diana, Anna Martorana, Girolamo Cirrincione.
Abstract
This article describes the development of nanostructured lipid carriers (NLC) as colloidal carriers for two antitumor compounds that possess a remarkable antineoplastic activity. But their limited stability and low solubility in water could give a very low parenteral bioavailability. Results revealed an enhancement of the cytotoxicity effect of drug-loaded NLC on human prostate cancer (PC-3) and human hepatocellular carcinoma (HuH-6, HuH-7) cell lines with respect to that of both free drugs. Results of characterization studies strongly support the potential application of these drugs-loaded NLC as prolonged delivery systems for lipophilic drugs by several administration routes, in particular for intravenous administration.Entities:
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Year: 2007 PMID： 17364869 DOI： 10.1080/10717540600739914
Source DB: PubMed Journal: Drug Deliv ISSN： 1071-7544 Impact factor: 6.419