Literature DB >> 17364571

The association of oral hydroxyurea therapy with improved cognitive functioning in sickle cell disease.

Eve Puffer1, Jeffrey Schatz, Carla W Roberts.   

Abstract

This study examined potential cognitive benefits of oral hydroxyurea therapy for children with sickle cell disease (SCD). Cognitive abilities of 15 children with SCD on hydroxyurea were compared to 50 other children with SCD, controlling for demographics and hematocrit. Children on hydroxyurea scored significantly higher on tests of verbal comprehension, fluid reasoning, and general cognitive ability than children not on the drug. The data therefore provide preliminary evidence of cognitive benefits of hydroxyurea. Mechanisms for this effect may be improved blood/oxygen supply to the brain or reduced fatigue and illness.

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Year:  2007        PMID： 17364571     DOI： 10.1080/09297040600584626

Source DB:  PubMed          Journal:  Child Neuropsychol        ISSN： 0929-7049            Impact factor:   2.500


  15 in total

1.  Higher executive abilities following a blood transfusion in children and young adults with sickle cell disease.

Authors:  Anna M Hood; Allison A King; Melanie E Fields; Andria L Ford; Kristin P Guilliams; Monica L Hulbert; Jin-Moo Lee; Desiree A White
Journal:  Pediatr Blood Cancer       Date:  2019-07-03       Impact factor: 3.167

Review 2.  Update on the use of hydroxyurea therapy in sickle cell disease.

Authors:  Trisha E Wong; Amanda M Brandow; Wendy Lim; Richard Lottenberg
Journal:  Blood       Date:  2014-10-06       Impact factor: 22.113

3.  Disease severity and slower psychomotor speed in adults with sickle cell disease.

Authors:  Dana R Jorgensen; Andrea Metti; Meryl A Butters; Joseph M Mettenburg; Caterina Rosano; Enrico M Novelli
Journal:  Blood Adv       Date:  2017-09-14

Review 4.  Chronic organ failure in adult sickle cell disease.

Authors:  Elliott Vichinsky
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2017-12-08

5.  Developmental Screening in Pediatric Sickle Cell Disease: Disease-Related Risk and Screening Outcomes in 4 Year Olds.

Authors:  Jeffrey Schatz; Alyssa Schlenz; Laura Reinman; Kelsey Smith; Carla W Roberts
Journal:  J Dev Behav Pediatr       Date:  2017-10       Impact factor: 2.225

Review 6.  How I use hydroxyurea to treat young patients with sickle cell anemia.

Authors:  Russell E Ware
Journal:  Blood       Date:  2010-03-11       Impact factor: 22.113

7.  Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia.

Authors:  Elliott P Vichinsky; Lynne D Neumayr; Jeffrey I Gold; Michael W Weiner; Randall R Rule; Diana Truran; Jeffrey Kasten; Barry Eggleston; Karen Kesler; Lillian McMahon; Eugene P Orringer; Thomas Harrington; Karen Kalinyak; Laura M De Castro; Abdullah Kutlar; Cynthia J Rutherford; Cage Johnson; Joel David Bessman; Lanetta B Jordan; F Daniel Armstrong
Journal:  JAMA       Date:  2010-05-12       Impact factor: 56.272

Review 8.  Beyond the definitions of the phenotypic complications of sickle cell disease: an update on management.

Authors:  Samir K Ballas; Muge R Kesen; Morton F Goldberg; Gerard A Lutty; Carlton Dampier; Ifeyinwa Osunkwo; Winfred C Wang; Carolyn Hoppe; Ward Hagar; Deepika S Darbari; Punam Malik
Journal:  ScientificWorldJournal       Date:  2012-08-01

9.  Cognitive performance as a predictor of healthcare transition in sickle cell disease.

Authors:  Anjelica C Saulsberry-Abate; Marita Partanen; Jerlym S Porter; Pradeep S B Podila; Jason R Hodges; Allison A King; Winfred C Wang; Jane E Schreiber; Xiwen Zhao; Guolian Kang; Lisa M Jacola; Jane S Hankins
Journal:  Br J Haematol       Date:  2021-02-11       Impact factor: 6.998

10.  Sociodemographic and Biomedical Correlates of Developmental Delay in 2- and 4-Year-Olds with Sickle Cell Disease.

Authors:  Jeffrey Schatz; Laura Reinman; Sarah E Bills; Julia D Johnston
Journal:  J Dev Behav Pediatr       Date:  2021-09-24       Impact factor: 2.988
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