Literature DB >> 1736363

The Son of sevenless gene product: a putative activator of Ras.

L Bonfini1, C A Karlovich, C Dasgupta, U Banerjee.   

Abstract

The Son of sevenless (Sos) gene functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases. The Sos gene has now been isolated and sequenced. Its product is a 1595-amino acid protein similar to the CDC25 protein in Saccharomyces cerevisiae, a guanine nucleotide exchange factor that activates Ras. These results imply a role for the ras pathway in Drosophila neuronal development.

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Year:  1992        PMID： 1736363     DOI： 10.1126/science.1736363

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  68 in total

1.  Involvement of a small GTP-binding protein (G protein) regulator, small G protein GDP dissociation stimulator, in antiapoptotic cell survival signaling.

Authors:  A Takakura; J Miyoshi; H Ishizaki; M Tanaka; A Togawa; Y Nishizawa; H Yoshida; S i Nishikawa; Y Takai
Journal:  Mol Biol Cell       Date:  2000-05       Impact factor: 4.138

2.  Ras-guanine nucleotide exchange factor sos2 is dispensable for mouse growth and development.

Authors:  L M Esteban; A Fernández-Medarde; E López; K Yienger; C Guerrero; J M Ward; L Tessarollo; E Santos
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

Review 3.  Building an ommatidium one cell at a time.

Authors:  Justin P Kumar
Journal:  Dev Dyn       Date:  2012-01       Impact factor: 3.780

Review 4.  The discovery of modular binding domains: building blocks of cell signalling.

Authors:  Bruce J Mayer
Journal:  Nat Rev Mol Cell Biol       Date:  2015-09-30       Impact factor: 94.444

Review 5.  RAS-targeted therapies: is the undruggable drugged?

Authors:  Amanda R Moore; Scott C Rosenberg; Frank McCormick; Shiva Malek
Journal:  Nat Rev Drug Discov       Date:  2020-06-11       Impact factor: 84.694

6.  Neuronal development in the Drosophila retina: the sextra gene defines an inhibitory component in the developmental pathway of R7 photoreceptor cells.

Authors:  R Rogge; R Cagan; A Majumdar; T Dulaney; U Banerjee
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

7.  A Drosophila model of multiple endocrine neoplasia type 2.

Authors:  Renee D Read; Paul J Goodfellow; Elaine R Mardis; Nancy Novak; Jon R Armstrong; Ross L Cagan
Journal:  Genetics       Date:  2005-06-18       Impact factor: 4.562

8.  Recognition of methylated peptides by Drosophila melanogaster polycomb chromodomain.

Authors:  Richard S L Stein; Nan Li; Wei He; Elizabeth Komives; Wei Wang
Journal:  J Proteome Res       Date:  2013-02-04       Impact factor: 4.466

Review 9.  Role of mitogen-activated protein kinases and protein kinase C in regulating low-density lipoprotein receptor expression.

Authors:  Kamal D Mehta
Journal:  Gene Expr       Date:  2002

10.  Endothelin-1 couples betaPix to p66Shc: role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt.

Authors:  Ahmed Chahdi; Andrey Sorokin
Journal:  Mol Biol Cell       Date:  2008-04-02       Impact factor: 4.138
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