| Literature DB >> 17363258 |
Takuma Komatsu1, Tomoya Hirano, Chalermkiat Songkram, Emiko Kawachi, Hiroyuki Kagechika.
Abstract
Thyroid hormones play important roles in growth, development and homeostasis, and disruption of their functions induces serious disease, so novel synthetic thyroid hormone analogues are candidates for clinical application. We designed and synthesized novel diphenylamine derivatives with a thiazolidinedione moiety as the terminal polar group as thyroid hormone receptor (TR) antagonists. Compounds bearing an appropriately sized N-alkyl group showed antagonistic activities towards both the hTRalpha1 and hTRbeta1 subtypes.Entities:
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Year: 2007 PMID： 17363258 DOI： 10.1016/j.bmc.2007.02.053
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641