| Literature DB >> 17362997 |
Jon Infante1, Pascual Sánchez-Juan, Ignacio Mateo, Eloy Rodríguez-Rodríguez, Coro Sánchez-Quintana, Javier Llorca, Ana Fontalba, Jesús Terrazas, Agustín Oterino, José Berciano, Onofre Combarros.
Abstract
Poly (ADP-ribose) polymerase-1 (PARP-1) is involved in crucial pathogenic events in Parkinson's disease (PD). We studied the effect of promoter variations of PARP-1 gene on the risk for PD in a case-control association study comprising 146 PD patients and 161 controls from Northern Spain. Three polymorphisms from the promoter region of PARP-1 gene were analyzed: -410C/T, -1672G/A, and a (CA)n microsatellite. A protective effect against PD was found for heterozygosity at (-410) (OR 0.44) and (CA)n microsatellite (OR 0.53) polymorphisms, and heterozygosity at (-1672) polymorphism delayed by 4 years on the onset age of PD. Variations in the regulatory region of PARP-1 gene might modify the risk for PD.Entities:
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Year: 2007 PMID： 17362997 DOI： 10.1016/j.jns.2007.02.008
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181