| Literature DB >> 17361995 |
Michael N Greco1, Michael J Hawkins, Eugene T Powell, Harold R Almond, Lawrence de Garavilla, Jeffrey Hall, Lisa K Minor, Yuanping Wang, Thomas W Corcoran, Enrico Di Cera, Angelene M Cantwell, Savvas N Savvides, Bruce P Damiano, Bruce E Maryanoff.
Abstract
A series of beta-carboxamido-phosphon(in)ic acids (2) was identified as a new structural motif for obtaining potent inhibitors of human mast cell chymase. For example, 1-naphthyl derivative 5f had an IC50 value of 29 nM and (E)-styryl derivative 6g had an IC50 value of 3.5 nM. An X-ray structure for 5f.chymase revealed key interactions within the enzyme active site. Compound 5f was selective for inhibiting chymase versus eight serine proteases. Compound 6h was orally bioavailable in rats (F=39%), and orally efficacious in a hamster model of inflammation.Entities:
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Year: 2007 PMID： 17361995 DOI： 10.1021/jm0700619
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446