Literature DB >> 17360182

Phosphonoxins: rational design and discovery of a potent nucleotide anti-Giardia agent.

Dae-Hwan Suk1, Dominik Rejman, Christine C Dykstra, Radek Pohl, Krzysztof W Pankiewicz, Steven E Patterson.   

Abstract

Phosphonoxins, a new class of synthetic, rationally designed anti-microbial agents, are described. From this class a sub-micromolar inhibitor of Giardia trophozoite growth has been identified.

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Year:  2007        PMID： 17360182     DOI： 10.1016/j.bmcl.2007.02.063

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Phosphonoxins III: synthesis of α-aminophosphonate analogs of antifungal polyoxins with anti-Giardia activity.

Authors:  Michael Staake; Jay Chauhan; Ding Zhou; Aaron Shanker; Atasi De Chatterjee; Siddhartha Das; Steven E Patterson
Journal:  Org Lett       Date:  2010-10-15       Impact factor: 6.005

2.  RNAi-Mediated Specific Gene Silencing as a Tool for the Discovery of New Drug Targets in Giardia lamblia; Evaluation Using the NADH Oxidase Gene.

Authors:  Jaime Marcial-Quino; Saúl Gómez-Manzo; Francisco Fierro; Yadira Rufino-González; Daniel Ortega-Cuellar; Edgar Sierra-Palacios; America Vanoye-Carlo; Abigail González-Valdez; Angélica Torres-Arroyo; Jesús Oria-Hernández; Horacio Reyes-Vivas
Journal:  Genes (Basel)       Date:  2017-11-03       Impact factor: 4.096
  2 in total

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