Ren-zhi Wang1, Jian Yin, Chang-bao Su, Zu-yuan Ren, Yong Yao, Wei Tao. 1. Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China. wangrz@126.com
Abstract
OBJECTIVE: To evaluate the possibility of extended transsphenoidal approach for removing the giant and invasive pituitary adenomas. METHODS: The clinical data of 64 cases with giant and invasive pituitary adenoma treated by extended transsphenoidal approach were studied retrospectively. RESULTS: Among 64 patients, 51 had total resection and 13 had subtotal resection. 26 patients occurred transient diabetes insipidus, 5 patients with transient cerebrospinal rhinorrhoea and 1 patient occurred acute hypopituitarism postoperatively. There were no death or intracranial infection. After operation, 8 patients get radiotherapy, 6 patients receive medicine treatment. Postoperative follow-up period was 3 months to 6 years. No regrowth or recurrence was seen. CONCLUSION: The extended transsphenoidal approach has been proved to a safe and effective method to remove the giant and invasive pituitary adenomas. Patients who got subtotal resection need be close followed-up and receive radiotherapy or medicine treatment it necessary.
OBJECTIVE: To evaluate the possibility of extended transsphenoidal approach for removing the giant and invasive pituitary adenomas. METHODS: The clinical data of 64 cases with giant and invasive pituitary adenoma treated by extended transsphenoidal approach were studied retrospectively. RESULTS: Among 64 patients, 51 had total resection and 13 had subtotal resection. 26 patients occurred transient diabetes insipidus, 5 patients with transient cerebrospinal rhinorrhoea and 1 patient occurred acute hypopituitarism postoperatively. There were no death or intracranial infection. After operation, 8 patients get radiotherapy, 6 patients receive medicine treatment. Postoperative follow-up period was 3 months to 6 years. No regrowth or recurrence was seen. CONCLUSION: The extended transsphenoidal approach has been proved to a safe and effective method to remove the giant and invasive pituitary adenomas. Patients who got subtotal resection need be close followed-up and receive radiotherapy or medicine treatment it necessary.
Authors: Gilberto Ka Kit Leung; Michele Mae Ann Yuen; Michelle Mae Ann Yuen; Wing Sun Chow; Philip Yat Hang Tse; Wai Man Lui Journal: Pituitary Date: 2012-06 Impact factor: 4.107