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Literature DB >> 17358907

Structural polymorphism of the actin-espin system: a prototypical system of filaments and linkers in stereocilia.

Kirstin R Purdy¹, James R Bartles, Gerard C L Wong.

Abstract

We examine the interaction between cytoskeletal F-actin and espin 3A, a prototypical actin bundling protein found in sensory cell microvilli, including ear cell stereocilia. Espin induces twist distortions in F-actin as well as facilitates bundle formation. Mutations in one of the two F-actin binding sites of espin, which have been implicated in deafness, can tune espin-actin interactions and radically transform the system's phase behavior. These results are compared to recent theoretical work on the general phase behavior linker-rod systems.

Entities: Disease

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Year: 2007 PMID： 17358907 PMCID： PMC2843914 DOI： 10.1103/PhysRevLett.98.058105

Source DB: PubMed Journal: Phys Rev Lett ISSN： 0031-9007 Impact factor: 9.161

19 in total

1. Bending stiffness of a crystalline actin bundle.

Authors: Jennifer H Shin; L Mahadevan; P T So; Paul Matsudaira
Journal: J Mol Biol Date: 2004-03-19 Impact factor: 5.469

2. Structure of actin cross-linked with alpha-actinin: a network of bundles.

Authors: O Pelletier; E Pokidysheva; L S Hirst; N Bouxsein; Y Li; C R Safinya
Journal: Phys Rev Lett Date: 2003-09-30 Impact factor: 9.161

3. Higher-order assembly of microtubules by counterions: from hexagonal bundles to living necklaces.

Authors: Daniel J Needleman; Miguel A Ojeda-Lopez; Uri Raviv; Herbert P Miller; Leslie Wilson; Cyrus R Safinya
Journal: Proc Natl Acad Sci U S A Date: 2004-11-08 Impact factor: 11.205

4. Isotropic to nematic liquid crystalline phase transition of F-actin varies from continuous to first order.

Authors: Jorge Viamontes; Patrick W Oakes; Jay X Tang
Journal: Phys Rev Lett Date: 2006-09-13 Impact factor: 9.161

5. Direct observation of counterion organization in F-actin polyelectrolyte bundles.

Authors: T E Angelini; H Liang; W Wriggers; G C L Wong
Journal: Eur Phys J E Soft Matter Date: 2005-04 Impact factor: 1.890

6. Balanced levels of Espin are critical for stereociliary growth and length maintenance.

Authors: Agnieszka Rzadzinska; Mark Schneider; Konrad Noben-Trauth; James R Bartles; Bechara Kachar
Journal: Cell Motil Cytoskeleton Date: 2005-11

7. Espin contains an additional actin-binding site in its N terminus and is a major actin-bundling protein of the Sertoli cell-spermatid ectoplasmic specialization junctional plaque.

Authors: B Chen; A Li; D Wang; M Wang; L Zheng; J R Bartles
Journal: Mol Biol Cell Date: 1999-12 Impact factor: 4.138

8. Mutations of ESPN cause autosomal recessive deafness and vestibular dysfunction.

Authors: S Naz; A J Griffith; S Riazuddin; L L Hampton; J F Battey; S N Khan; S Riazuddin; E R Wilcox; T B Friedman
Journal: J Med Genet Date: 2004-08 Impact factor: 6.318

9. The organization of actin filaments in the stereocilia of cochlear hair cells.

Authors: L G Tilney; D J Derosier; M J Mulroy
Journal: J Cell Biol Date: 1980-07 Impact factor: 10.539

10. Small espin: a third actin-bundling protein and potential forked protein ortholog in brush border microvilli.

Authors: J R Bartles; L Zheng; A Li; A Wierda; B Chen
Journal: J Cell Biol Date: 1998-10-05 Impact factor: 10.539

16 in total

1. Targeting of the hair cell proteins cadherin 23, harmonin, myosin XVa, espin, and prestin in an epithelial cell model.

Authors: Lili Zheng; Jing Zheng; Donna S Whitlon; Jaime García-Añoveros; James R Bartles
Journal: J Neurosci Date: 2010-05-26 Impact factor: 6.167

Review 2. Dynamic length regulation of sensory stereocilia.

Authors: Uri Manor; Bechara Kachar
Journal: Semin Cell Dev Biol Date: 2008-07-25 Impact factor: 7.727

3. Correlation of actin crosslinker and capper expression levels with stereocilia growth phases.

Authors: Matthew R Avenarius; Katherine W Saylor; Megan R Lundeberg; Phillip A Wilmarth; Jung-Bum Shin; Kateri J Spinelli; James M Pagana; Leonardo Andrade; Bechara Kachar; Dongseok Choi; Larry L David; Peter G Barr-Gillespie
Journal: Mol Cell Proteomics Date: 2013-12-07 Impact factor: 5.911

Structural polymorphism of the actin-espin system: a prototypical system of filaments and linkers in stereocilia.

1. Bending stiffness of a crystalline actin bundle.

2. Structure of actin cross-linked with alpha-actinin: a network of bundles.

3. Higher-order assembly of microtubules by counterions: from hexagonal bundles to living necklaces.

4. Isotropic to nematic liquid crystalline phase transition of F-actin varies from continuous to first order.

5. Direct observation of counterion organization in F-actin polyelectrolyte bundles.

6. Balanced levels of Espin are critical for stereociliary growth and length maintenance.

7. Espin contains an additional actin-binding site in its N terminus and is a major actin-bundling protein of the Sertoli cell-spermatid ectoplasmic specialization junctional plaque.

8. Mutations of ESPN cause autosomal recessive deafness and vestibular dysfunction.

9. The organization of actin filaments in the stereocilia of cochlear hair cells.

10. Small espin: a third actin-bundling protein and potential forked protein ortholog in brush border microvilli.

1. Targeting of the hair cell proteins cadherin 23, harmonin, myosin XVa, espin, and prestin in an epithelial cell model.

Review 2. Dynamic length regulation of sensory stereocilia.

3. Correlation of actin crosslinker and capper expression levels with stereocilia growth phases.

4. α-Catenin Structure and Nanoscale Dynamics in Solution and in Complex with F-Actin.

5. Elasto-plastic response of reversibly crosslinked biopolymer bundles.

6. Actin-induced dimerization of palladin promotes actin-bundling.

7. Cooperativity and frustration in protein-mediated parallel actin bundles.

8. Micro- and macrorheological properties of isotropically cross-linked actin networks.

9. Structural and viscoelastic properties of actin networks formed by espin or pathologically relevant espin mutants.

10. Helical twist controls the thickness of F-actin bundles.