| Literature DB >> 17358082 |
Na Li1, Jian-Lin Wu, Toshiaki Hasegawa, Jun-Ichi Sakai, Li-Ming Bai, Li-Yan Wang, Saori Kakuta, Yumiko Furuya, Hirotsugu Ogura, Takao Kataoka, Akihiro Tomida, Takashi Tsuruo, Masayoshi Ando.
Abstract
Six new lignans (1-6), along with 14 known compounds, were obtained from Peperomia duclouxii. The new structures were elucidated mainly by the analysis of their NMR and MS data. The absolute configurations of 1-6 were determined by comparing their optical rotations or CD spectra with those of known compounds. In cytotoxic and MDR reversal cell activity assays, compound 3 showed cancer cell growth inhibitory activity against VA-13 and HepG2 cells, with IC50 values of 5.3 and 13.2 microg/mL, and more potent effects on calcein accumulation in MDR 2780AD cells than verapamil, a positive control. Compound 6 showed anti-inflammatory activity using an ICAM-1 assay (induction of the intercellular adhesion molecule-1), stimulated by IL-1alpha and TNF-alpha.Entities:
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Year: 2007 PMID： 17358082 DOI： 10.1021/np0604533
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050