Literature DB >> 1735771

Intrathecal synthesis of soluble class I antigens in multiple sclerosis.

J C Alvarez-Cermeño1, L M Villar, M Nocito, A Bootello, P González-Porqué.   

Abstract

We have studied the intrathecal synthesis of soluble class I antigens (sHLA), reflected by the index IH = (CSF sHLA/serum sHLA)/(CSF albumin/serum albumin), in multiple sclerosis (MS). IH was increased in patients in relapse, but normal in patients in remission; these findings show that there is a high lymphocyte activation within the central nervous system in patients with clinically active MS.

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Year:  1992        PMID： 1735771     DOI： 10.1016/0165-5728(92)90032-g

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  3 in total

1.  Soluble HLA measurement in saliva and cerebrospinal fluid in Caucasian patients with multiple sclerosis: a preliminary study.

Authors:  Irena Adamashvili; Alireza Minagar; Eduardo Gonzalez-Toledo; Liubov Featherston; Roger E Kelley
Journal:  J Neuroinflammation       Date:  2005-06-02       Impact factor: 8.322

Review 2.  Salivary Biomarkers: Future Approaches for Early Diagnosis of Neurodegenerative Diseases.

Authors:  Giovanni Schepici; Serena Silvestro; Oriana Trubiani; Placido Bramanti; Emanuela Mazzon
Journal:  Brain Sci       Date:  2020-04-21

3.  Saliva soluble HLA as a potential marker of response to interferon-beta 1a in multiple sclerosis: a preliminary study.

Authors:  Alireza Minagar; Irena Adamashvili; Roger E Kelley; Eduardo Gonzalez-Toledo; Jerry McLarty; Stacy J Smith
Journal:  J Neuroinflammation       Date:  2007-07-01       Impact factor: 8.322
  3 in total

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