OBJECTIVE: To investigate the relationship between the expression of matrix metalloproteinase-2 (MMP-2) and clinical significance of laryngeal squamous cell carcinomas (LSCC). METHOD: Expression of the MMP-2 was detected by immunohistochemical method in 63 cases of LSCC, 20 cases of adjacent safety margin (ASM) and 18 cases of vocal cord polyp (VCP). RESULT: The positive percentage of active MMP-2 expression were 66.7%, 33. 3% and 15. 0%, in LSCC,VCP and ASM respectively. Significant differences ( P <0. 05) were observed among the three group; there was a significant differences in the expression of MMP-2 among the different pathologic degree I , II , III; no significant difference in the expression of MMP-2 between lymphoid metastasis and no lymphoid metastasis ( P >0. 05); Age and clinical stage did not change the expressions of the MMP-2 expression ( P <0. 05). CONCLUSION: MMP-2 probably plays an important role in the carcinogenesis and progression of LSCC. But it may be an unnecessary factor in the metastases of LSCC.
OBJECTIVE: To investigate the relationship between the expression of matrix metalloproteinase-2 (MMP-2) and clinical significance of laryngeal squamous cell carcinomas (LSCC). METHOD: Expression of the MMP-2 was detected by immunohistochemical method in 63 cases of LSCC, 20 cases of adjacent safety margin (ASM) and 18 cases of vocal cord polyp (VCP). RESULT: The positive percentage of active MMP-2 expression were 66.7%, 33. 3% and 15. 0%, in LSCC,VCP and ASM respectively. Significant differences ( P <0. 05) were observed among the three group; there was a significant differences in the expression of MMP-2 among the different pathologic degree I , II , III; no significant difference in the expression of MMP-2 between lymphoid metastasis and no lymphoid metastasis ( P >0. 05); Age and clinical stage did not change the expressions of the MMP-2 expression ( P <0. 05). CONCLUSION:MMP-2 probably plays an important role in the carcinogenesis and progression of LSCC. But it may be an unnecessary factor in the metastases of LSCC.