| Literature DB >> 17357271 |
A K Singal1, A S Rosman, W A Bauman, M A Korsten.
Abstract
Bowel problems after SCI can be debilitating. Colonic inertia as a result of decreased parasympathetic (S2-4) stimulation of the left colon and rectosigmoid seems to be the principal abnormality accounting for DWE. The conventional measures used for decades have poor results in many people. Neostigmine, an anticholinesterase inhibitor, appears to be a more physiological agent for these individuals. The combination of neostigmine + glycopyrrolate infusion has shown encouraging results after intravenous administration and studies are under way to assess the efficacy of neostigmine by other routes.Entities:
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Year: 2006 PMID: 17357271
Source DB: PubMed Journal: Adv Med Sci ISSN: 1896-1126 Impact factor: 3.287