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Literature DB >> 173567

Interaction between dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and cyclic adenosine-3',5'-monophosphate in neoplastic and normal human mammary tissue.

G W Oertel, P Benes, G Hoffmann, E Schuy.

Abstract

When total DHEA, G-6-PDH activity, and c-AMP were determined in human neoplastic mammary tissue and corresponding normal tissue the G-6-PDH activity in the former tissue greatly exceeded that found in normal tissue. On the other hand, a remarkable decrease of total DHEA and c-AMP could be detected in cancer tissue, hinting at the participation of DHEA in the intracellular regulation of G-6-PDH and c-AMP levels.

Entities: Chemical Disease Gene Species

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Year: 1975 PMID： 173567 DOI： 10.1007/bf02326746

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

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References

10 in total

1. Effects of DHEA or its sulfoconjugates upon C-AMP phosphodiesterase.

Authors: G W Oertel; P Benes; A Rauer; H Rauer
Journal: Experientia Date: 1975-01-15

2. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

3. Cyclic 3',5'-nucleotide phosphodiesterase properties of the enzyme of human blood platelets.

Authors: S Y Song; W Y Cheung
Journal: Biochim Biophys Acta Date: 1971-09-22

4. A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate.

Authors: B L Brown; J D Albano; R P Ekins; A M Sgherzi
Journal: Biochem J Date: 1971-02 Impact factor: 3.857

5. Interaction between dehydroepiandrosterone, cyclic adenosine-3',5'-monophosphate and glucose-6-phosphate-dehydrogenase in normal and diseased subjects.

Authors: G W Oertel; P Benes; M Schirazi; H Holzmann; G Hoffmann
Journal: Experientia Date: 1974-08-15

6. [On the determination of ketosteroids with 2,4-dinitrophenylhydrazine. II. Application of the method in plasma analysis].

Authors: L Treiber; W Rindt; G W Oertel
Journal: Z Klin Chem Klin Biochem Date: 1967-05

Interaction between dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and cyclic adenosine-3',5'-monophosphate in neoplastic and normal human mammary tissue.

1. Effects of DHEA or its sulfoconjugates upon C-AMP phosphodiesterase.

2. Protein measurement with the Folin phenol reagent.

3. Cyclic 3',5'-nucleotide phosphodiesterase properties of the enzyme of human blood platelets.

4. A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate.

5. Interaction between dehydroepiandrosterone, cyclic adenosine-3',5'-monophosphate and glucose-6-phosphate-dehydrogenase in normal and diseased subjects.

6. [On the determination of ketosteroids with 2,4-dinitrophenylhydrazine. II. Application of the method in plasma analysis].

7. Cytostatic effects of G-6-PDH inhibitors in cell cultures from normal and neoplastic tissue.

8. Plasma and urinary dehydroepiandrosterone in cancer.

9. The effects of steroids on glucose-6-phosphate dehydrogenase.

10. [Effect of dehydroepiandrosterone on the mitotic cycle].