Literature DB >> 17356621

Phenotyping transgenic embryonic murine hearts using optical coherence tomography.

Michael W Jenkins1, Pankti Patel, Huayun Deng, Monica M Montano, Michiko Watanabe, Andrew M Rollins.   

Abstract

We used optical coherence tomography (OCT) to characterize the morphological phenotype of embryonic murine hearts discerning hexamethylene-bis-acetamide-inducible protein 1 (HEXIM1) mutants from their wild-type littermates. At E12.5 and E13.5 murine embryos were excised from the mother, the hearts were removed, and 3D OCT data sets were obtained from each heart in the litter. Next, we segmented the morphological borders to obtain cavity volumes and wall thicknesses. The mutant hearts exhibited increased ventricular chamber volume and decreased compact myocardium wall thickness when compared with their wild-type littermates. Also, the E13.5 HEXIM1 -/- embryo was distinguished by morphological asymmetry (underdeveloped left side).

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Year:  2007        PMID： 17356621     DOI： 10.1364/ao.46.001776

Source DB:  PubMed          Journal:  Appl Opt        ISSN： 1559-128X            Impact factor:   1.980


  19 in total

1.  Rotationally acquired four-dimensional optical coherence tomography of embryonic chick hearts using retrospective gating on the common central A-scan.

Authors:  Christoph M Happel; Jan Thommes; Lars Thrane; Jrög Männer; Tobias Ortmaier; Bodo Heimann; Talat Mesud Yelbuz
Journal:  J Biomed Opt       Date:  2011-09       Impact factor: 3.170

2.  Rotational imaging optical coherence tomography for full-body mouse embryonic imaging.

Authors:  Chen Wu; Narendran Sudheendran; Manmohan Singh; Irina V Larina; Mary E Dickinson; Kirill V Larin
Journal:  J Biomed Opt       Date:  2016-02       Impact factor: 3.170

3.  Ultrahigh-speed optical coherence tomography imaging and visualization of the embryonic avian heart using a buffered Fourier Domain Mode Locked laser.

Authors:  M W Jenkins; D C Adler; M Gargesha; R Huber; F Rothenberg; J Belding; M Watanabe; D L Wilson; J G Fujimoto; A M Rollins
Journal:  Opt Express       Date:  2007-05-14       Impact factor: 3.894

4.  Optical coherence tomography for high-resolution imaging of mouse development in utero.

Authors:  Saba H Syed; Kirill V Larin; Mary E Dickinson; Irina V Larina
Journal:  J Biomed Opt       Date:  2011-04       Impact factor: 3.170

5.  Optical coherence tomography guided microinjections in live mouse embryos: high-resolution targeted manipulation for mouse embryonic research.

Authors:  Saba H Syed; Andrew J Coughlin; Monica D Garcia; Shang Wang; Jennifer L West; Kirill V Larin; Irina V Larina
Journal:  J Biomed Opt       Date:  2015-05       Impact factor: 3.170

6.  Embryonic aortic arch hemodynamics are a functional biomarker for ethanol-induced congenital heart defects [Invited].

Authors:  Lindsy M Peterson; Shi Gu; Ganga Karunamuni; Michael W Jenkins; Michiko Watanabe; Andrew M Rollins
Journal:  Biomed Opt Express       Date:  2017-02-24       Impact factor: 3.732

7.  Heart wall velocimetry and exogenous contrast-based cardiac flow imaging in Drosophila melanogaster using Doppler optical coherence tomography.

Authors:  Michael A Choma; Melissa J Suter; Benjamin J Vakoc; Brett E Bouma; Guillermo J Tearney
Journal:  J Biomed Opt       Date:  2010 Sep-Oct       Impact factor: 3.170

8.  Cardiac neural crest ablation results in early endocardial cushion and hemodynamic flow abnormalities.

Authors:  Pei Ma; Shi Gu; Ganga H Karunamuni; Michael W Jenkins; Michiko Watanabe; Andrew M Rollins
Journal:  Am J Physiol Heart Circ Physiol       Date:  2016-08-19       Impact factor: 4.733

Review 9.  Optical coherence tomography for embryonic imaging: a review.

Authors:  Raksha Raghunathan; Manmohan Singh; Mary E Dickinson; Kirill V Larin
Journal:  J Biomed Opt       Date:  2016-05-01       Impact factor: 3.170

10.  Denoising and 4D visualization of OCT images.

Authors:  Madhusudhana Gargesha; Michael W Jenkins; Andrew M Rollins; David L Wilson
Journal:  Opt Express       Date:  2008-08-04       Impact factor: 3.894
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