Literature DB >> 17355599

The genetic background of Streptococcus pneumoniae affects protection in mice immunized with PspA.

Xiangyun He1, Larry S McDaniel.   

Abstract

Anti-PspA antibodies are less efficient at protecting mice against certain pneumococcal strains. Immunization with PspA from EF5668 provided better protection against WU2 (a different capsular serotype and PspA family) than against EF5668. To understand the role of the pneumococcal genetic background in anti-PspA-mediated protection, we constructed a mutant of WU2 expressing pspA from EF5668. Both passive and active immunization demonstrated that the genetic background impacted the protection mediated by anti-PspA antibodies. We localized the protection-eliciting region to the first 122 amino acid residues of the N-terminus of the alpha-helical domain of PspA/EF5668.

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Year:  2007        PMID： 17355599     DOI： 10.1111/j.1574-6968.2006.00516.x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  7 in total

1.  Immunization with Pneumococcal Surface Protein K of Nonencapsulated Streptococcus pneumoniae Provides Protection in a Mouse Model of Colonization.

Authors:  Lance E Keller; Xiao Luo; Justin A Thornton; Keun-Seok Seo; Bo Youn Moon; D Ashley Robinson; Larry S McDaniel
Journal:  Clin Vaccine Immunol       Date:  2015-08-26

2.  Immunization with pneumolysin protects against both retinal and global damage caused by Streptococcus pneumoniae endophthalmitis.

Authors:  Melissa E Sanders; Erin W Norcross; Quincy C Moore; Jonathan Fratkin; Hilary Thompson; Mary E Marquart
Journal:  J Ocul Pharmacol Ther       Date:  2010-10-29       Impact factor: 2.671

3.  Epidemiology of Streptococcus pneumoniae in France before introduction of the PCV-13 vaccine.

Authors:  N Grall; O Hurmic; M Al Nakib; M Longo; C Poyart; M-C Ploy; E Varon; J Raymond
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2011-04-18       Impact factor: 3.267

4.  Immunization with PspA incorporated into a poly(ethylene oxide) matrix elicits protective immunity against Streptococcus pneumoniae.

Authors:  Quincy C Moore; LaShundra Johnson; Michael Repka; Larry S McDaniel
Journal:  Clin Vaccine Immunol       Date:  2007-04-25

5.  Interaction of pneumococcal histidine triad proteins with human complement.

Authors:  Merit Melin; Emmanuel Di Paolo; Leena Tikkanen; Hanna Jarva; Cecile Neyt; Helena Käyhty; Seppo Meri; Jan Poolman; Merja Väkeväinen
Journal:  Infect Immun       Date:  2010-03-01       Impact factor: 3.441

6.  Pneumococcal virulence gene expression and host cytokine profiles during pathogenesis of invasive disease.

Authors:  Layla K Mahdi; Abiodun D Ogunniyi; Kim S LeMessurier; James C Paton
Journal:  Infect Immun       Date:  2007-11-26       Impact factor: 3.441

7.  Polyamine transporter in Streptococcus pneumoniae is essential for evading early innate immune responses in pneumococcal pneumonia.

Authors:  Aswathy N Rai; Justin A Thornton; John Stokes; Imran Sunesara; Edwin Swiatlo; Bindu Nanduri
Journal:  Sci Rep       Date:  2016-06-01       Impact factor: 4.379
  7 in total

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