Literature DB >> 17355201

A high throughput luminescent assay for glycogen synthase kinase-3beta inhibitors.

Andrea Baki1, Attila Bielik, László Molnár, Györgyi Szendrei, György M Keserü.   

Abstract

A high throughput luminescent assay based on the Kinase-Glo() system (Promega, Madison, WI) has been developed for screening against glycogen synthase kinase-3beta (GSK-3beta). Careful optimization of assay parameters allowed us to develop a robust, reproducible, and sensitive assay. Its usefulness has been demonstrated in a high throughput screening run when screening 55,000 compounds. This campaign yielded five chemical classes of hits, including several highly potent GSK-3beta inhibitors.

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Year:  2007        PMID： 17355201     DOI： 10.1089/adt.2006.029

Source DB:  PubMed          Journal:  Assay Drug Dev Technol        ISSN： 1540-658X            Impact factor:   1.738


  26 in total

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5.  Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: two relevant therapeutic targets for neurological disorders.

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Journal:  ACS Chem Neurosci       Date:  2014-01-17       Impact factor: 4.418

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7.  Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease.

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Authors:  Tobias A M Gulder; Hanna Hong; Jhonny Correa; Ekaterina Egereva; Jutta Wiese; Johannes F Imhoff; Harald Gross
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10.  Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis.

Authors:  Irene G Salado; Miriam Redondo; Murilo L Bello; Concepción Perez; Nicole F Liachko; Brian C Kraemer; Laetitia Miguel; Magalie Lecourtois; Carmen Gil; Ana Martinez; Daniel I Perez
Journal:  J Med Chem       Date:  2014-03-12       Impact factor: 7.446
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