Literature DB >> 17354171

Evaluation of antifungal and DNA-damaging activities of alkaloids from branches of Porcelia macrocarpa.

João Henrique G Lago1, Mariana H Chaves, Mariane Cruz C Ayres, Débora G Agripino, Maria Cláudia M Young.   

Abstract

Bioactivity-guided fractionation of the alkaloidal fractions of the CH2Cl2 extract from branches of Porcelia macrocarpa using mutant yeast strains of Saccharomyces cerevisiae and fungi Cladosporium cladosporioides and C. sphaerospermum led to the isolation of bioactive alkaloids: two tetrahydrobenzylisoquinolines (1 and 2), two aporphines (3 and 4), one proaporphine (5), one oxoaporphine (6), four azantraquinones (7-10) and four azafluorenones (11-14). The alkaloids cleistopholine (7) and 6-methoxycleistopholine (8) showed the highest fungitoxic activity while the mixture of 6- and 7-methoxyonychine (12+13) and 6,7-dimethoxyonychine (14) showed a weak DNA-damaging potential.

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Year:  2007        PMID： 17354171     DOI： 10.1055/s-2007-967108

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  5 in total

1.  Role of heme in the antifungal activity of the azaoxoaporphine alkaloid sampangine.

Authors:  Ameeta K Agarwal; Tao Xu; Melissa R Jacob; Qin Feng; Michael C Lorenz; Larry A Walker; Alice M Clark
Journal:  Eukaryot Cell       Date:  2007-12-21

2.  Synthetic and biological studies on a cyclopolypeptide of plant origin.

Authors:  Rajiv Dahiya; Akhilesh Kumar
Journal:  J Zhejiang Univ Sci B       Date:  2008-05       Impact factor: 3.066

3.  Antibacterial and antifungal potentials of the solvents extracts from Eryngium caeruleum, Notholirion thomsonianum and Allium consanguineum.

Authors:  Abdul Sadiq; Sadiq Ahmad; Rahmat Ali; Fawad Ahmad; Sajjad Ahmad; Anwar Zeb; Muhammad Ayaz; Farhat Ullah; Abu Nasar Siddique
Journal:  BMC Complement Altern Med       Date:  2016-11-24       Impact factor: 3.659

4.  Antileishmanial Effects of Acetylene Acetogenins from Seeds of Porcelia macrocarpa (Warm.) R.E. Fries (Annonaceae) and Semisynthetic Derivatives.

Authors:  Ivanildo A Brito; Fernanda Thevenard; Thais A Costa-Silva; Samuel S Oliveira; Rodrigo L O R Cunha; Emerson A de Oliveira; Patricia Sartorelli; Rafael C Guadagnin; Maiara M Romanelli; Andre G Tempone; João Henrique G Lago
Journal:  Molecules       Date:  2022-01-28       Impact factor: 4.411

5.  Bioactive azafluorenone alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep.

Authors:  Supaluk Prachayasittikul; Patumporn Manam; Maneekarn Chinworrungsee; Chartchalerm Isarankura-Na-Ayudhya; Somsak Ruchirawat; Virapong Prachayasittikul
Journal:  Molecules       Date:  2009-11-03       Impact factor: 4.411
  5 in total

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