Literature DB >> 17354170

Two major urinary metabolites of scutellarin in rats.

Feng Qiu1, HongJun Xia, TieYing Zhang, Xin Di, Gexia Qu, XinSheng Yao.   

Abstract

Urinary metabolites of scutellarin, the main effective constituent of breviscapine, a cerebrovascular and cardiovascular drug consisting of total flavonoids of Erigeron breviscapus, were investigated in rats. Two major metabolites were isolated from the urine of rats following oral administration of scutellarin and identified as scutellarein 6,7-di- O-beta-D-glucuronide (M1) and scutellarein (M2), respectively, on the basis of chemical and spectroscopic evidence. M1 was reported as a metabolite of scutellarin for the first time.

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Year:  2007        PMID： 17354170     DOI： 10.1055/s-2007-967128

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  3 in total

1.  Antioxidant capacity of the leaf extract obtained from Arrabidaea chica cultivated in Southern Brazil.

Authors:  Jackeline Tiemy Guinoza Siraichi; Daniele Fernanda Felipe; Lara Zampar Serra Brambilla; Melissa Junqueira Gatto; Vânia Aparecida Terra; Alessandra Lourenco Cecchini; Lucia Elaine Ranieri Cortez; Edson Rodrigues-Filho; Diógenes Aparício Garcia Cortez
Journal:  PLoS One       Date:  2013-08-29       Impact factor: 3.240

2.  Synthesis of Scutellarein Derivatives with a Long Aliphatic Chain and Their Biological Evaluation against Human Cancer Cells.

Authors:  Guanghui Ni; Yanling Tang; Minxin Li; Yuefeng He; Gaoxiong Rao
Journal:  Molecules       Date:  2018-02-01       Impact factor: 4.411

3.  Triglyceride-mimetic prodrugs of scutellarin enhance oral bioavailability by promoting intestinal lymphatic transport and avoiding first-pass metabolism.

Authors:  Xinran Wang; Cai Zhang; Ning Han; Juyuan Luo; Shuofeng Zhang; Chunguo Wang; Zhanhong Jia; Shouying Du
Journal:  Drug Deliv       Date:  2021-12       Impact factor: 6.419
  3 in total

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