PURPOSE: To prospectively investigate the effect of thyroid arterial embolization on hyperthyroid Graves' disease in selected patients. MATERIAL AND METHODS: Twenty-eight patients with hyperthyroidism caused by Graves' disease were enrolled to undergo thyroid arterial embolization and followed up for 12-22 months. Twenty-two patients had three thyroid arteries embolized and six patients two arteries. Serum thyroid hormone, thyroid-stimulating hormone (TSH), and autoimmune function were tested before and after embolization in all patients. RESULTS: Of 28 patients, 22 (78.6%) became euthyroid, five improved (17.8%), and one had temporary improvement followed by recurrence (3.6%). No serious complications occurred. Compared with the pre-embolization values, serum concentrations of thyroid hormone increased temporarily on day 3 post-embolization, dropped substantially after 1 and 2 months, and returned to nearly normal at 6 and 12 months post-embolization. TSH dropped on day 3, increased after 1 and 2 months, and returned to normal after 6 and 12 months. Thyroid antibodies TGAb and TMAb declined on day 3 to normal range, rose after 1 month, dropped to normal again after 2 months, and were slightly increased at 6 and 12 months follow-up. CONCLUSION: Thyroid arterial embolization may be an effective approach for patients with hyperthyroidism caused by Graves' disease.
PURPOSE: To prospectively investigate the effect of thyroid arterial embolization on hyperthyroid Graves' disease in selected patients. MATERIAL AND METHODS: Twenty-eight patients with hyperthyroidism caused by Graves' disease were enrolled to undergo thyroid arterial embolization and followed up for 12-22 months. Twenty-two patients had three thyroid arteries embolized and six patients two arteries. Serum thyroid hormone, thyroid-stimulating hormone (TSH), and autoimmune function were tested before and after embolization in all patients. RESULTS: Of 28 patients, 22 (78.6%) became euthyroid, five improved (17.8%), and one had temporary improvement followed by recurrence (3.6%). No serious complications occurred. Compared with the pre-embolization values, serum concentrations of thyroid hormone increased temporarily on day 3 post-embolization, dropped substantially after 1 and 2 months, and returned to nearly normal at 6 and 12 months post-embolization. TSH dropped on day 3, increased after 1 and 2 months, and returned to normal after 6 and 12 months. Thyroid antibodies TGAb and TMAb declined on day 3 to normal range, rose after 1 month, dropped to normal again after 2 months, and were slightly increased at 6 and 12 months follow-up. CONCLUSION: Thyroid arterial embolization may be an effective approach for patients with hyperthyroidism caused by Graves' disease.
Authors: Marek Dedecjus; Józef Tazbir; Zbigniew Kaurzel; Grzegorz Strózyk; Arkadiusz Zygmunt; Andrzej Lewiński; Jan Brzeziński Journal: Thyroid Res Date: 2009-07-31
Authors: Grzegorz Kaminski; Andrzej Jaroszuk; Ariadna Zybek; Krzysztof Brzozowski; Piotr Piasecki; Piotr Ziecina; Marek Ruchala Journal: Endocrine Date: 2013-10-22 Impact factor: 3.633