OBJECTIVE: To characterize the neuropsychological profile of an extended family with unipolar depression (UPD) and other forms of affective illness. METHOD: We administered a battery of neuropsychological tasks measuring various aspects of executive function and visual and verbal memory to 49 individuals in 1 extended family. Six participants had 1 lifetime episode of major depression (MDE-S), 15 were diagnosed with recurrent major depression (MDE-R), 11 had another DSM-IV diagnosis and 17 subjects were unaffected. RESULTS: After controlling for multiple confounding factors, including mood and medication, the MDE-R sample made significantly more errors than unaffected relatives on the Stroop Task, a measure of cognitive control. CONCLUSION: There may be at least 1 subtype of UPD characterized by a state-independent deficit in cognitive control.
OBJECTIVE: To characterize the neuropsychological profile of an extended family with unipolar depression (UPD) and other forms of affective illness. METHOD: We administered a battery of neuropsychological tasks measuring various aspects of executive function and visual and verbal memory to 49 individuals in 1 extended family. Six participants had 1 lifetime episode of major depression (MDE-S), 15 were diagnosed with recurrent major depression (MDE-R), 11 had another DSM-IV diagnosis and 17 subjects were unaffected. RESULTS: After controlling for multiple confounding factors, including mood and medication, the MDE-R sample made significantly more errors than unaffected relatives on the Stroop Task, a measure of cognitive control. CONCLUSION: There may be at least 1 subtype of UPD characterized by a state-independent deficit in cognitive control.
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