PURPOSE OF REVIEW: This paper reviews the effect of in-vitro fertilization on maternal and perinatal outcomes of pregnancy. RECENT FINDINGS: Few randomized, controlled trials have been published in this area due to inherent difficulties in studying this population of infertile women who require in-vitro fertilization. Systematic review of the literature identified published studies that consistently highlighted the higher incidence of maternal and perinatal morbidity associated with pregnancies following in-vitro fertilization. SUMMARY: Some prospective observational studies compare maternal and perinatal outcomes in in-vitro fertilization pregnancies. Larger studies show that adverse pregnancy outcomes such as preeclampsia, gestational hypertension, placental abruption, placenta praevia, and preterm delivery increase significantly with in-vitro fertilization. Perinatal adverse outcomes such as prematurity and those related to plurality of the pregnancy also increase. All patients undergoing in-vitro fertilization should have careful counselling regarding these increased risks prior to treatment.
PURPOSE OF REVIEW: This paper reviews the effect of in-vitro fertilization on maternal and perinatal outcomes of pregnancy. RECENT FINDINGS: Few randomized, controlled trials have been published in this area due to inherent difficulties in studying this population of infertilewomen who require in-vitro fertilization. Systematic review of the literature identified published studies that consistently highlighted the higher incidence of maternal and perinatal morbidity associated with pregnancies following in-vitro fertilization. SUMMARY: Some prospective observational studies compare maternal and perinatal outcomes in in-vitro fertilization pregnancies. Larger studies show that adverse pregnancy outcomes such as preeclampsia, gestational hypertension, placental abruption, placenta praevia, and preterm delivery increase significantly with in-vitro fertilization. Perinatal adverse outcomes such as prematurity and those related to plurality of the pregnancy also increase. All patients undergoing in-vitro fertilization should have careful counselling regarding these increased risks prior to treatment.
Authors: Amie Wilson; Victoria A Hodgetts-Morton; Ella J Marson; Alexandra D Markland; Eva Larkai; Argyro Papadopoulou; Arri Coomarasamy; Aurelio Tobias; Doris Chou; Olufemi T Oladapo; Malcolm J Price; Katie Morris; Ioannis D Gallos Journal: Cochrane Database Syst Rev Date: 2022-08-10
Authors: Erika L Rangel; Manuel Castillo-Angeles; Sarah Rae Easter; Rachel B Atkinson; Ankush Gosain; Yue-Yung Hu; Zara Cooper; Tanujit Dey; Eugene Kim Journal: JAMA Surg Date: 2021-10-01 Impact factor: 16.681