| Literature DB >> 17353147 |
Alfredo G Torres1, Lorena Milflores-Flores, J Gerardo Garcia-Gallegos, Shilpa D Patel, Angus Best, Roberto M La Ragione, Ygnacio Martinez-Laguna, Martin J Woodward.
Abstract
The ability of Escherichia coli O157:H7 to colonize the intestinal epithelia is dependent on the expression of intimin and other adhesins. The chromosome of E. coli O157:H7 carries two loci encoding long polar fimbriae (LPF). These fimbriae mediate adherence to epithelial cells and are associated with colonization of the intestine. In order to increase our knowledge about the conditions controlling their expression and their role in colonization of an animal model, the environmental cues that promote expression of lpf genes and the role of E. coli O157:H7 LPF in intestinal colonization of lambs were investigated. We found that expression of lpf1 was regulated in response to growth phase, osmolarity, and pH; that lpf2 transcription was stimulated during late exponential growth and iron depletion; and that LPF impacts the ability of E. coli O157:H7 to persist in the intestine of infected 6-week-old lambs.Entities:
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Year: 2007 PMID： 17353147 DOI： 10.1016/j.ijmm.2007.01.005
Source DB: PubMed Journal: Int J Med Microbiol ISSN： 1438-4221 Impact factor: 3.473