BACKGROUND: Breast cancer is the most common cancer among women, with variable outcomes, justifying a continuous search for new parameters to predict accurate prognosis and indicate suitable adjuvant therapy for patients. MATERIALS AND METHODS: Fourty-four stage I-III breast cancer specimens were investigated immunohistochemically for the expression of cyclooxygenase-2 enzyme (COX-2), hormone receptors, tumor suppressor gene p53, oncogene HER2 and proliferation marker Ki-67. Additionally, twelve specimens were also investigated for the presence of the phosphorylated extracellular signal-regulated kinase (pERK). RESULTS: It was demonstrated that expressions of biological markers were related to each other (ER to p53 and Ki-67, COX-2 to ER, PgR, Ki-67 and p53, Ki-67 to p53 and PgR, p53 to PgR). CONCLUSION: Our data indicate that concomitant immunohistochemical evaluation of cyclooxygenase-2, hormone receptors, p53 and Ki-67 may be of clinical value in determining an accurate prognosis.
BACKGROUND:Breast cancer is the most common cancer among women, with variable outcomes, justifying a continuous search for new parameters to predict accurate prognosis and indicate suitable adjuvant therapy for patients. MATERIALS AND METHODS: Fourty-four stage I-III breast cancer specimens were investigated immunohistochemically for the expression of cyclooxygenase-2 enzyme (COX-2), hormone receptors, tumor suppressor gene p53, oncogene HER2 and proliferation marker Ki-67. Additionally, twelve specimens were also investigated for the presence of the phosphorylated extracellular signal-regulated kinase (pERK). RESULTS: It was demonstrated that expressions of biological markers were related to each other (ER to p53 and Ki-67, COX-2 to ER, PgR, Ki-67 and p53, Ki-67 to p53 and PgR, p53 to PgR). CONCLUSION: Our data indicate that concomitant immunohistochemical evaluation of cyclooxygenase-2, hormone receptors, p53 and Ki-67 may be of clinical value in determining an accurate prognosis.
Authors: Andrés Castellanos-Martín; Sonia Castillo-Lluva; María Del Mar Sáez-Freire; Adrián Blanco-Gómez; Lourdes Hontecillas-Prieto; Carmen Patino-Alonso; Purificación Galindo-Villardon; Luis Pérez Del Villar; Carmen Martín-Seisdedos; María Isidoro-Garcia; María Del Mar Abad-Hernández; Juan Jesús Cruz-Hernández; César Augusto Rodríguez-Sánchez; Rogelio González-Sarmiento; Diego Alonso-López; Javier De Las Rivas; Begoña García-Cenador; Javier García-Criado; Do Yup Lee; Benjamin Bowen; Wolfgang Reindl; Trent Northen; Jian-Hua Mao; Jesús Pérez-Losada Journal: Genome Biol Date: 2015-02-21 Impact factor: 13.583