Marek Bebenek1, Danuta Duś, Joanna Koźlak. 1. First Deptartment of Surgical Oncology, Regional Comprehensive Cancer Center, 53-413 Wroclaw, Poland. bebmar@dco.com.pl
Abstract
BACKGROUND: Bones belong to the most frequent localizations of breast cancer metastases. Several studies on female breast malignancies have indicated that Fas/Fas-ligand status may have a significant impact on survival. Hence, the aim of our study was to determine if these molecules might serve as the predictors of skeletal dissemination in radically-treated breast cancer patients. PATIENTS AND METHODS: Tumor samples from 147 radically-treated breast cancer patients were studied immunohistochemically for Fas/Fas-ligand expression. RESULTS: Both Fas and Fas-ligand expression in the primary tumor were considerably less frequent among breast cancer patients with bone metastases compared to women without skeletal spread. Moreover, negative staining for Fas or the lack of Fas-ligand expression proved to be significant predictors for the survival free from bone metastases under univariate analysis. CONCLUSION: Our results suggest that the probability of bone metastases may be assessed on the basis of Fas/Fas-ligand expression in primary breast cancer. Consequently, their determination seems crucial for further prognosis and determination of adjuvant treatment.
BACKGROUND: Bones belong to the most frequent localizations of breast cancer metastases. Several studies on female breast malignancies have indicated that Fas/Fas-ligand status may have a significant impact on survival. Hence, the aim of our study was to determine if these molecules might serve as the predictors of skeletal dissemination in radically-treated breast cancerpatients. PATIENTS AND METHODS: Tumor samples from 147 radically-treated breast cancerpatients were studied immunohistochemically for Fas/Fas-ligand expression. RESULTS: Both Fas and Fas-ligand expression in the primary tumor were considerably less frequent among breast cancerpatients with bone metastases compared to women without skeletal spread. Moreover, negative staining for Fas or the lack of Fas-ligand expression proved to be significant predictors for the survival free from bone metastases under univariate analysis. CONCLUSION: Our results suggest that the probability of bone metastases may be assessed on the basis of Fas/Fas-ligand expression in primary breast cancer. Consequently, their determination seems crucial for further prognosis and determination of adjuvant treatment.
Authors: Christopher I Li; Justin E Mirus; Yuzheng Zhang; Arturo B Ramirez; Jon J Ladd; Ross L Prentice; Martin W McIntosh; Samir M Hanash; Paul D Lampe Journal: Breast Cancer Res Treat Date: 2012-08-19 Impact factor: 4.872
Authors: Monika Holubova; Michaela Miklikova; Martin Leba; Daniel Georgiev; Pavel Jindra; Martin Caprnda; Rachele Ciccocioppo; Peter Kruzliak; Daniel Lysak Journal: J Cancer Res Clin Oncol Date: 2016-09-10 Impact factor: 4.553