| Literature DB >> 17350877 |
Anna Kloda1, Evgeny Petrov, Grischa R Meyer, Thom Nguyen, Annette C Hurst, Livia Hool, Boris Martinac.
Abstract
Microbial cells constitutively express the Large Conductance Mechanosensitive Channel which opens in response to stretch forces in the lipid bilayer. The channel protein forms a homopentamer with each subunit containing two transmembrane regions and gates via the bilayer mechanism evoked by hydrophobic mismatch and changes in the membrane curvature and/or transbilayer pressure profile. During the stationary phase and during osmotic shock the channel protein is up-regulated to prevent cell lysis. Pharmacological potential of MscL may involve discovery of new age antibiotics to combat multiple drug-resistant bacterial strains.Entities:
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Year: 2007 PMID： 17350877 DOI： 10.1016/j.biocel.2007.02.003
Source DB: PubMed Journal: Int J Biochem Cell Biol ISSN： 1357-2725 Impact factor: 5.085