| Literature DB >> 17350840 |
Michael F Gross1, Serge Beaudoin, Grant McNaughton-Smith, George S Amato, Neil A Castle, Christine Huang, Anruo Zou, Weifeng Yu.
Abstract
A collection of aryl sulfonamido indanes based on the lead compound 1 was synthesized and evaluated for Kv1.5 inhibitory activity. Kv1.5 inhibitors have the potential to be atrium-selective agents for treatment of atrial fibrillation. (1R,2R)-1 has an IC(50) of 0.033microM against Kv1.5 and is selective against other cardiac ion channels, including hERG.Entities:
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Year: 2007 PMID： 17350840 DOI： 10.1016/j.bmcl.2007.02.052
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823