| Literature DB >> 17350833 |
Bengt Erik Haug1, Wenche Stensen, John S Svendsen.
Abstract
Antimicrobial peptides have been recognized as a novel class of antibiotics, and several candidates are currently in clinical trials. In this work, a tripeptide derivative containing 4-iodo phenylalanine has been derivatized through the Suzuki-Miyaura cross-coupling. This has enabled the rapid and efficient synthesis of an array of tripeptide derivatives encompassing novel biaryl moieties. The peptide derivatives show high activity against Gram-positive bacteria.Entities:
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Year: 2006 PMID： 17350833 DOI： 10.1016/j.bmcl.2006.12.049
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823