| Literature DB >> 17350259 |
William J Watkins1, Lee Chong, Aesop Cho, Ramona Hilgenkamp, Maria Ludwikow, Negar Garizi, Nadeem Iqbal, John Barnard, Rajeshwar Singh, Deidre Madsen, Karen Lolans, Olga Lomovskaya, Uma Oza, Padmapriya Kumaraswamy, Andrea Blecken, Shuang Bai, David J Loury, David C Griffith, Michael N Dudley.
Abstract
Further structure-activity relationships of a novel series of fungal efflux pump inhibitors with respect to potentiation of the activity of fluconazole against strains of C. albicans and C. glabrata over-expressing ABC-type efflux pumps are systematically explored. Rat protein binding and pharmacokinetics of selected analogues are reported.Entities:
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Year: 2007 PMID： 17350259 DOI： 10.1016/j.bmcl.2007.02.047
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823