| Literature DB >> 17349978 |
Katsuhiko Nishimura1, Kazuhiko Nakamura, A Anitha, Kazuo Yamada, Masatsugu Tsujii, Yoshimi Iwayama, Eiji Hattori, Tomoko Toyota, Nori Takei, Taishi Miyachi, Yasuhide Iwata, Katsuaki Suzuki, Hideo Matsuzaki, Masayoshi Kawai, Yoshimoto Sekine, Kenji Tsuchiya, Gen-ichi Sugihara, Shiro Suda, Yasuomi Ouchi, Toshiro Sugiyama, Takeo Yoshikawa, Norio Mori.
Abstract
Autism is a severe neurodevelopmental disorder defined by social and communication deficits and ritualistic-repetitive behaviors that are detectable in early childhood. Brain-derived neurotrophic factor (BDNF) plays a critical role in the pathogenesis of autism. In this study, we examined the SNP- and haplotypic-association of BDNF with autism in a trios-based association study (the Autism Genetic Resource Exchange). We also examined the expression of BDNF mRNA in the peripheral blood lymphocytes of drug-naïve autism patients and control subjects. In the TDT of autism trios, the SNP haplotype combinations showed significant associations in the autism group. BDNF expression in the drug-naïve autistic group was found to be significantly higher than in the control group. We suggest that BDNF has a possible role in the pathogenesis of autism through its neurotrophic effects on the serotonergic system.Entities:
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Year: 2007 PMID： 17349978 DOI： 10.1016/j.bbrc.2007.02.135
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575