| Literature DB >> 17349871 |
Danielle Carpenter1, Hind Abushama, Sándor Bereczky, Anna Färnert, Ingegerd Rooth, Marita Troye-Blomberg, Rupert J Quinnell, Marie-Anne Shaw.
Abstract
This study builds upon the established genetic control of antimalarial immune responses and prior association studies by using a family-based approach, transmission disequilibrium testing, to identify immune response genes that influence antibody responses to Plasmodium falciparum infection in an endemic Tanzanian population. Candidate polymorphisms are within the interleukin-1 (IL-1) gene cluster, the IL-10 promoter, Major histocompatibility complex class II and III, the 5q31-q33 region, and the T-Cell Receptor beta variable region. There was a significant association between the IL1RN alleles and total IgE. Weak evidence for association was present between polymorphisms in the IL10 promoter region and both anti-P falciparum IgE and IgG4 antibodies.Entities:
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Year: 2006 PMID： 17349871 DOI： 10.1016/j.humimm.2006.12.002
Source DB: PubMed Journal: Hum Immunol ISSN： 0198-8859 Impact factor: 2.850