Literature DB >> 17349860

Alterations of serotonin transmission in schizophrenia.

Anissa Abi-Dargham1.   

Abstract

A role for serotonin alterations in the pathophysiology of schizophrenia has long been suspected because of the psychotogenic effects of serotonergic agonists and the therapeutic effects of 5-HT(2) antagonism. This chapter is a review of the evidence derived from pharmacological studies, postmortem, and imaging studies that have assessed the role of serotonin transmission in schizophrenia. While a clear picture of specific serotonergic alterations in schizophrenia has not emerged despite much research, this review reinforces a modulatory role of serotonergic agents on dopamine transmission in schizophrenia, which may contribute to the therapeutic effects of atypical antipsychotics.

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Year:  2007        PMID： 17349860     DOI： 10.1016/S0074-7742(06)78005-9

Source DB:  PubMed          Journal:  Int Rev Neurobiol        ISSN： 0074-7742            Impact factor:   3.230


  24 in total

Review 1.  Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection.

Authors:  Jeffrey A Lieberman; Frank P Bymaster; Herbert Y Meltzer; Ariel Y Deutch; Gary E Duncan; Christine E Marx; June R Aprille; Donard S Dwyer; Xin-Min Li; Sahebarao P Mahadik; Ronald S Duman; Joseph H Porter; Josephine S Modica-Napolitano; Samuel S Newton; John G Csernansky
Journal:  Pharmacol Rev       Date:  2008-09       Impact factor: 25.468

2.  Variation in Dopamine D2 and Serotonin 5-HT2A Receptor Genes is Associated with Working Memory Processing and Response to Treatment with Antipsychotics.

Authors:  Giuseppe Blasi; Pierluigi Selvaggi; Leonardo Fazio; Linda Antonella Antonucci; Paolo Taurisano; Rita Masellis; Raffaella Romano; Marina Mancini; Fengyu Zhang; Grazia Caforio; Teresa Popolizio; Jose Apud; Daniel R Weinberger; Alessandro Bertolino
Journal:  Neuropsychopharmacology       Date:  2015-01-07       Impact factor: 7.853

3.  Multiple SNP Set Analysis for Genome-Wide Association Studies Through Bayesian Latent Variable Selection.

Authors:  Zhao-Hua Lu; Hongtu Zhu; Rebecca C Knickmeyer; Patrick F Sullivan; Stephanie N Williams; Fei Zou
Journal:  Genet Epidemiol       Date:  2015-10-30       Impact factor: 2.135

Review 4.  Critical age windows for neurodevelopmental psychiatric disorders: evidence from animal models.

Authors:  Eva M Marco; Simone Macrì; Giovanni Laviola
Journal:  Neurotox Res       Date:  2010-07-07       Impact factor: 3.911

5.  Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.

Authors:  E R Bychkov; M R Ahmed; V V Gurevich; J L Benovic; E V Gurevich
Journal:  Neurobiol Dis       Date:  2011-07-20       Impact factor: 5.996

6.  Functional interrelations between nucleus raphé dorsalis and nucleus raphé medianus: a dual probe microdialysis study of glutamate-stimulated serotonin release.

Authors:  David J Mokler; Jason R Dugal; Jill M Hoffman; Peter J Morgane
Journal:  Brain Res Bull       Date:  2008-10-26       Impact factor: 4.077

7.  Reduced dopamine transporter expression in the amygdala of subjects diagnosed with schizophrenia.

Authors:  Matej Markota; Jessica Sin; Harry Pantazopoulos; Rebecca Jonilionis; Sabina Berretta
Journal:  Schizophr Bull       Date:  2014-06-16       Impact factor: 9.306

8.  Constitutive genetic deletion of the growth regulator Nogo-A induces schizophrenia-related endophenotypes.

Authors:  Roman Willi; Oliver Weinmann; Christine Winter; Julia Klein; Reinhard Sohr; Lisa Schnell; Benjamin K Yee; Joram Feldon; Martin E Schwab
Journal:  J Neurosci       Date:  2010-01-13       Impact factor: 6.167

Review 9.  The neural underpinnings of cognitive flexibility and their disruption in psychotic illness.

Authors:  James A Waltz
Journal:  Neuroscience       Date:  2016-06-07       Impact factor: 3.590

10.  Manganese-enhanced magnetic resonance imaging reveals increased DOI-induced brain activity in a mouse model of schizophrenia.

Authors:  Natalia V Malkova; Joseph J Gallagher; Collin Z Yu; Russell E Jacobs; Paul H Patterson
Journal:  Proc Natl Acad Sci U S A       Date:  2014-06-02       Impact factor: 11.205
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