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Literature DB >> 17349628

Site specific phosphorylation of cytochrome c oxidase subunits I, IVi1 and Vb in rabbit hearts subjected to ischemia/reperfusion.

Ji-Kang Fang¹, Subbuswamy K Prabu, Naresh B Sepuri, Haider Raza, Hindupur K Anandatheerthavarada, Domenico Galati, Joseph Spear, Narayan G Avadhani.

Abstract

We have mapped the sites of ischemia/reperfusion-induced phosphorylation of cytochrome c oxidase (CcO) subunits in rabbit hearts by using a combination of Blue Native gel/Tricine gel electrophoresis and nano-LC-MS/MS approaches. We used precursor ion scanning combined with neutral loss scanning and found that mature CcO subunit I was phosphorylated at tandem Ser115/Ser116 positions, subunit IVi1 at Thr52 and subunit Vb at Ser40. These sites are highly conserved in mammalian species. Molecular modeling suggests that phosphorylation sites of subunit I face the inter membrane space while those of subunits IVi1 and Vb face the matrix side.

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Year: 2007 PMID： 17349628 PMCID： PMC1995084 DOI： 10.1016/j.febslet.2007.02.042

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

23 in total

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