E D Newman1, R J Kurland. 1. Department of Rheumatology, Geisinger Medical Center, Danville, Pennsylvania 17822.
Abstract
OBJECTIVE: To explore alterations in energy utilization as a potential etiology for weakness in polymyositis and dermatomyositis (PM/DM). METHODS: P-31 magnetic resonance spectroscopy studies were performed in patients with acute and treated PM/DM and in normal controls, at rest and with exercise. RESULTS: Patients with acute and treated PM/DM showed increased ratios of inorganic phosphate to phosphocreatine (PCr) during exercise, with loss of ATP disproportional to loss of PCr. CONCLUSION: This study demonstrates changes in energy utilization in PM/DM, thus supporting the notion of a metabolic etiology for the weakness associated with these diseases.
OBJECTIVE: To explore alterations in energy utilization as a potential etiology for weakness in polymyositis and dermatomyositis (PM/DM). METHODS:P-31 magnetic resonance spectroscopy studies were performed in patients with acute and treated PM/DM and in normal controls, at rest and with exercise. RESULTS:Patients with acute and treated PM/DM showed increased ratios of inorganic phosphate to phosphocreatine (PCr) during exercise, with loss of ATP disproportional to loss of PCr. CONCLUSION: This study demonstrates changes in energy utilization in PM/DM, thus supporting the notion of a metabolic etiology for the weakness associated with these diseases.