Literature DB >> 17348827

Recent progress in discovery and development of antimitotic agents.

Alex Kiselyov1, Konstantin V Balakin, Sergey E Tkachenko, Nikolay Savchuk, Alexandre V Ivachtchenko.   

Abstract

This review highlights structural diversity of antimitotic agents. In particular, we emphasized current antimitotic therapies based on modulation of microtubule dynamics. With several successful anticancer drugs on the market and numerous compounds in clinical developments, tubulin-binding agents remain among the most important categories of anticancer agents. Compounds targeting mitotic kinases and kinesins are also discussed.

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Year:  2007        PMID： 17348827     DOI： 10.2174/187152007780058650

Source DB:  PubMed          Journal:  Anticancer Agents Med Chem        ISSN： 1871-5206            Impact factor:   2.505


  10 in total

1.  N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines.

Authors:  Jonathan A Stefely; Rahul Palchaudhuri; Patricia A Miller; Rebecca J Peterson; Garrett C Moraski; Paul J Hergenrother; Marvin J Miller
Journal:  J Med Chem       Date:  2010-04-22       Impact factor: 7.446

2.  Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents.

Authors:  Kyoko Nakagawa-Goto; Pei-Chi Wu; Chin-Yu Lai; Ernest Hamel; Hao Zhu; Liying Zhang; Takashi Kozaka; Emika Ohkoshi; Masuo Goto; Kenneth F Bastow; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2011-02-01       Impact factor: 7.446

3.  Variations in the colchicine-binding domain provide insight into the structural switch of tubulin.

Authors:  Audrey Dorléans; Benoît Gigant; Raimond B G Ravelli; Patrick Mailliet; Vincent Mikol; Marcel Knossow
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-05       Impact factor: 11.205

4.  Substituted 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Dora Carrion; Olga Cruz-Lopez; Manlio Tolomeo; Stefania Grimaudo; Antonietta Di Cristina; Maria Rosaria Pipitone; Jan Balzarini; Andrea Brancale; Ernest Hamel
Journal:  Bioorg Med Chem       Date:  2010-06-01       Impact factor: 3.641

5.  Design, synthesis, and SAR studies of 4-substituted methoxylbenzoyl-aryl-thiazoles analogues as potent and orally bioavailable anticancer agents.

Authors:  Yan Lu; Chien-Ming Li; Zhao Wang; Jianjun Chen; Michael L Mohler; Wei Li; James T Dalton; Duane D Miller
Journal:  J Med Chem       Date:  2011-06-07       Impact factor: 7.446

6.  Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Taradas Sarkar; Maria Dora Carrion; Olga Cruz-Lopez; Carlota Lopez Cara; Manlio Tolomeo; Stefania Grimaudo; Antonietta Di Cristina; Maria Rosaria Pipitone; Jan Balzarini; Roberto Gambari; Lampronti Ilaria; Roberto Saletti; Andrea Brancale; Ernest Hamel
Journal:  Bioorg Med Chem       Date:  2008-08-17       Impact factor: 3.641

7.  Microtubule S-glutathionylation as a potential approach for antimitotic agents.

Authors:  Wei Chen; Teresa Seefeldt; Alan Young; Xiaoying Zhang; Yong Zhao; John Ruffolo; Radhey S Kaushik; Xiangming Guan
Journal:  BMC Cancer       Date:  2012-06-15       Impact factor: 4.430

Review 8.  Stabilizing versus destabilizing the microtubules: a double-edge sword for an effective cancer treatment option?

Authors:  Daniele Fanale; Giuseppe Bronte; Francesco Passiglia; Valentina Calò; Marta Castiglia; Florinda Di Piazza; Nadia Barraco; Antonina Cangemi; Maria Teresa Catarella; Lavinia Insalaco; Angela Listì; Rossella Maragliano; Daniela Massihnia; Alessandro Perez; Francesca Toia; Giuseppe Cicero; Viviana Bazan
Journal:  Anal Cell Pathol (Amst)       Date:  2015-09-21       Impact factor: 2.916

9.  Securin enhances the anti-cancer effects of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075) in human colorectal cancer cells.

Authors:  Ho-Hsing Tseng; Qiu-Yu Chuah; Pei-Ming Yang; Chiung-Tong Chen; Jung-Chi Chao; Ming-Der Lin; Shu-Jun Chiu
Journal:  PLoS One       Date:  2012-04-26       Impact factor: 3.240

10.  Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers.

Authors:  Chun Hei Antonio Cheung; Huang-Hui Chen; Ching-Chuan Kuo; Chi-Yen Chang; Mohane S Coumar; Hsing-Pang Hsieh; Jang-Yang Chang
Journal:  Mol Cancer       Date:  2009-07-03       Impact factor: 27.401
  10 in total

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