BACKGROUND: The prognostic significance of the presence of tumour cells in the blood of gastric cancer patients remains unclear. Their occurrence and its association with the stage of disease and long-term survival was determined. PATIENTS AND METHODS: Fifty-seven patients with stage I-IV gastric cancer were divided into two groups: these with and these without circulating tumour cells that were identified as cytokeratin positive (CK+) cells among CD45- cells (obtained by sorting of CD45+ leukocytes). RESULTS: Tumour cells were detected prior surgery in the peripheral blood of 54.4% patients but no clear association with the stage of disease was observed. After gastrectomy detection rate was 21.1%. There was no significant difference in the 5-year survival of patients, with or without CK+ in the blood. CONCLUSION: The presence of circulating tumour cells is of no prognostic value in patients with resectable gastric cancer.
BACKGROUND: The prognostic significance of the presence of tumour cells in the blood of gastric cancerpatients remains unclear. Their occurrence and its association with the stage of disease and long-term survival was determined. PATIENTS AND METHODS: Fifty-seven patients with stage I-IV gastric cancer were divided into two groups: these with and these without circulating tumour cells that were identified as cytokeratin positive (CK+) cells among CD45- cells (obtained by sorting of CD45+ leukocytes). RESULTS:Tumour cells were detected prior surgery in the peripheral blood of 54.4% patients but no clear association with the stage of disease was observed. After gastrectomy detection rate was 21.1%. There was no significant difference in the 5-year survival of patients, with or without CK+ in the blood. CONCLUSION: The presence of circulating tumour cells is of no prognostic value in patients with resectable gastric cancer.
Authors: Katarina Kolostova; Rafal Matkowski; Robert Gürlich; Krzysztof Grabowski; Katarzyna Soter; Robert Lischke; Jan Schützner; Vladimir Bobek Journal: Cytotechnology Date: 2015-04-11 Impact factor: 2.058
Authors: P Kolodziejczyk; A Pituch-Noworolska; G Drabik; J Kulig; A Szczepanik; M Sierzega; A Gurda; T Popiela; M Zembala Journal: Br J Cancer Date: 2007-08-14 Impact factor: 7.640