BACKGROUND: The natural history and carcinogenicity of rare and novel HPV types is unclear. MATERIALS AND METHODS: From a total of 5,964 women tested for HPV by PCR and sequence analysis, Pap smears from 293 patients harbouring mono-infection with low-risk, undetermined-risk or novel HPV genotypes were investigated. RESULTS: Sixty-three percent of patients had ASC-US, 23% LSIL, 9% were negative and 5% had HSIL in cytology. Of 30 HPV types detected, 19 were of unknown risk (UR)-types including 3 novel genotypes. Four of the UR-HPVs (HPV 69, 30, 67 and 34) could be assigned as probable high-risk types and eight as low-risk types based on phylogenetical relationship. Morphology was not discriminative with regard to HPV type, but non-classical HPV-signs were generally present even in "normal" cytologies. CONCLUSION: HPV-typing is important for risk-adapted individual patient management. Women harbouring novel high-risk or probably high-risk HPVs require more intensive care than those bearing non high-risk infections.
BACKGROUND: The natural history and carcinogenicity of rare and novel HPV types is unclear. MATERIALS AND METHODS: From a total of 5,964 women tested for HPV by PCR and sequence analysis, Pap smears from 293 patients harbouring mono-infection with low-risk, undetermined-risk or novel HPV genotypes were investigated. RESULTS: Sixty-three percent of patients had ASC-US, 23% LSIL, 9% were negative and 5% had HSIL in cytology. Of 30 HPV types detected, 19 were of unknown risk (UR)-types including 3 novel genotypes. Four of the UR-HPVs (HPV 69, 30, 67 and 34) could be assigned as probable high-risk types and eight as low-risk types based on phylogenetical relationship. Morphology was not discriminative with regard to HPV type, but non-classical HPV-signs were generally present even in "normal" cytologies. CONCLUSION: HPV-typing is important for risk-adapted individual patient management. Women harbouring novel high-risk or probably high-risk HPVs require more intensive care than those bearing non high-risk infections.
Authors: A Pähler Vor der Holte; I Fangk; S Glombitza; L Wilkens; H J Welkoborsky Journal: Eur Arch Otorhinolaryngol Date: 2019-12-12 Impact factor: 2.503
Authors: Angela Ri Meyrelles; Juliana D Siqueira; Pâmela P Dos Santos; Cristina B Hofer; Ronir R Luiz; Héctor N Seuánez; Gutemberg Almeida; Marcelo A Soares; Esmeralda A Soares; Elizabeth S Machado Journal: Mem Inst Oswaldo Cruz Date: 2016-02 Impact factor: 2.743
Authors: Anja Paehler Vor der Holte; Inger Fangk; Sabine Glombitza; Ludwig Wilkens; Hans J Welkoborsky Journal: Cancer Med Date: 2020-12-22 Impact factor: 4.452
Authors: Michel P Bihl; Luigi Tornillo; André B Kind; Ellen Obermann; Christoph Noppen; Rosemarie Chaffard; Patricia Wynne; Bruno Grilli; Anja Foerster; Luigi M Terracciano; Sylvia Hoeller Journal: Appl Immunohistochem Mol Morphol Date: 2017-03