Viroj Wiwanitkit1. 1. Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand 10330. wviroj@pioneer.netserv.chula.ac.th
Abstract
BACKGROUND: Dengue infection is a major public health problem. The mechanisms underlying severe bleeding in dengue DHF are not completely understood. It was proposed that the dengue virus nonstructural-1 protein (DNS1) generated antibodies to common epitopes on human blood clotting and integrin/adhesin proteins on the platelet. The proof on the functional correlation between DNS1 and platelet integrin/adhesin proteins is needed. METHODS: Here, the author used a new gene ontology technology to predict the molecular function and biological process of DNS1 and platelet integrin/adhesin protein, CD61. RESULT: According to this study, the author can identify no function and biological process of DNS1. Also, there is no existence of functional similarity between DNS1 and CD61. CONCLUSION: The hypothesis on role of molecular mimicry between DNS1 and CD61 is not supported in this study.
BACKGROUND:Dengue infection is a major public health problem. The mechanisms underlying severe bleeding in dengue DHF are not completely understood. It was proposed that the dengue virus nonstructural-1 protein (DNS1) generated antibodies to common epitopes on human blood clotting and integrin/adhesin proteins on the platelet. The proof on the functional correlation between DNS1 and platelet integrin/adhesin proteins is needed. METHODS: Here, the author used a new gene ontology technology to predict the molecular function and biological process of DNS1 and platelet integrin/adhesin protein, CD61. RESULT: According to this study, the author can identify no function and biological process of DNS1. Also, there is no existence of functional similarity between DNS1 and CD61. CONCLUSION: The hypothesis on role of molecular mimicry between DNS1 and CD61 is not supported in this study.
Authors: Priyanga Ranasinghe; Pathmasiri Ranasinghe; W P Kaushalya M Abeysekera; G A Sirimal Premakumara; Yashasvi S Perera; Padmalal Gurugama; Saman B Gunatilake Journal: Pharmacognosy Res Date: 2012-10