Literature DB >> 17347895

Estimating the number of coding mutations in genotypic and phenotypic driven N-ethyl-N-nitrosourea (ENU) screens: revisited.

David A Keays1, Taane G Clark, Thomas G Campbell, John Broxholme, William Valdar.   

Abstract

We recently described methods for estimating the number of N-ethyl-N-nitrosourea (ENU)-induced coding mutations in phenotypic and genotypic screens. In this article we revisit these methods, clarifying their application. In particular, we focus on the difference between unconditional and conditional probabilities. We also introduce a website to assist investigators in the application of these equations ( http://www.well.ox.ac.uk/enuMutRat ).

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Year:  2007        PMID： 17347895     DOI： 10.1007/s00335-006-0065-z

Source DB:  PubMed          Journal:  Mamm Genome        ISSN： 0938-8990            Impact factor:   2.957


  2 in total

1.  A gene-driven ENU-based approach to generating an allelic series in any gene.

Authors:  Mohamed Mohideen Quwailid; Alison Hugill; Neil Dear; Lucie Vizor; Sara Wells; Emma Horner; Shelly Fuller; Jessica Weedon; Hamish McMath; Paul Woodman; David Edwards; David Campbell; Susan Rodger; Joanne Carey; Ann Roberts; Pete Glenister; Zuzanna Lalanne; Nick Parkinson; Emma L Coghill; Richard McKeone; Sam Cox; John Willan; Andy Greenfield; David Keays; Saffron Brady; Nigel Spurr; Ian Gray; Jackie Hunter; Steve D M Brown; Roger D Cox
Journal:  Mamm Genome       Date:  2004-08       Impact factor: 2.957

2.  Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens.

Authors:  David A Keays; Taane G Clark; Jonathan Flint
Journal:  Mamm Genome       Date:  2006-03-03       Impact factor: 2.957
  2 in total
  12 in total

1.  Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in hematological parameters.

Authors:  Bernhard Aigner; Birgit Rathkolb; Martina Klempt; Sibylle Wagner; Dian Michel; Matthias Klaften; Jürgen Laufs; Boris Schneider; Reinhard Sedlmeier; Martin Hrabé de Angelis; Eckhard Wolf
Journal:  Mamm Genome       Date:  2011-05-08       Impact factor: 2.957

2.  An ENU-induced mutation in the lymphotoxin alpha gene impairs organogenesis of lymphoid tissues in C57BL/6 mice.

Authors:  Hongsheng Wang; Jianxun Feng; Chenfeng Qi; Herbert C Morse
Journal:  Biochem Biophys Res Commun       Date:  2008-03-31       Impact factor: 3.575

3.  ENU mutagenesis reveals a novel phenotype of reduced limb strength in mice lacking fibrillin 2.

Authors:  Gaynor Miller; Monica Neilan; Ruth Chia; Nabeia Gheryani; Natalie Holt; Annabelle Charbit; Sara Wells; Valter Tucci; Zuzanne Lalanne; Paul Denny; Elizabeth M C Fisher; Michael Cheeseman; Graham N Askew; T Neil Dear
Journal:  PLoS One       Date:  2010-02-09       Impact factor: 3.240

4.  A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy.

Authors:  Houman Ashrafian; Louise Docherty; Vincenzo Leo; Christopher Towlson; Monica Neilan; Violetta Steeples; Craig A Lygate; Tertius Hough; Stuart Townsend; Debbie Williams; Sara Wells; Dominic Norris; Sarah Glyn-Jones; John Land; Ivana Barbaric; Zuzanne Lalanne; Paul Denny; Dorota Szumska; Shoumo Bhattacharya; Julian L Griffin; Iain Hargreaves; Narcis Fernandez-Fuentes; Michael Cheeseman; Hugh Watkins; T Neil Dear
Journal:  PLoS Genet       Date:  2010-06-24       Impact factor: 5.917

5.  T-type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis control.

Authors:  Luca Mariotta; Tamara Ramadan; Dustin Singer; Adriano Guetg; Brigitte Herzog; Claudia Stoeger; Manuel Palacín; Tony Lahoutte; Simone M R Camargo; François Verrey
Journal:  J Physiol       Date:  2012-10-08       Impact factor: 5.182

6.  Insulin secretion from beta-cells is affected by deletion of nicotinamide nucleotide transhydrogenase.

Authors:  Kenju Shimomura; Juris Galvanovskis; Michelle Goldsworthy; Alison Hugill; Stephan Kaizak; Angela Lee; Nicholas Meadows; Mohamed Mohideen Quwailid; Jan Rydström; Lydia Teboul; Fran Ashcroft; Roger D Cox
Journal:  Methods Enzymol       Date:  2009       Impact factor: 1.600

7.  An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning.

Authors:  C A French; X Jin; T G Campbell; E Gerfen; M Groszer; S E Fisher; R M Costa
Journal:  Mol Psychiatry       Date:  2011-08-30       Impact factor: 15.992

8.  Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise.

Authors:  Nadia C Whitelaw; Suyinn Chong; Daniel K Morgan; Colm Nestor; Timothy J Bruxner; Alyson Ashe; Eleanore Lambley; Richard Meehan; Emma Whitelaw
Journal:  Genome Biol       Date:  2010-11-19       Impact factor: 13.583

9.  An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse.

Authors:  Lucia Daxinger; Sarah K Harten; Harald Oey; Trevor Epp; Luke Isbel; Edward Huang; Nadia Whitelaw; Anwyn Apedaile; Anabel Sorolla; Joan Yong; Vandhana Bharti; Joanne Sutton; Alyson Ashe; Zhenyi Pang; Nathan Wallace; Daniel J Gerhardt; Marnie E Blewitt; Jeffrey A Jeddeloh; Emma Whitelaw
Journal:  Genome Biol       Date:  2013       Impact factor: 13.583

10.  A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development.

Authors:  Alyson Ashe; Daniel K Morgan; Nadia C Whitelaw; Timothy J Bruxner; Nicola K Vickaryous; Liza L Cox; Natalie C Butterfield; Carol Wicking; Marnie E Blewitt; Sarah J Wilkins; Gregory J Anderson; Timothy C Cox; Emma Whitelaw
Journal:  Genome Biol       Date:  2008-12-19       Impact factor: 13.583
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