Literature DB >> 17346956

Glutamate-induced cell death in neuronal HT22 cells is attenuated by extracts from St. John's wort (Hypericum perforatum L.).

Anja Breyer1, Matthias Elstner, Thomas Gillessen, Dieter Weiser, Erich Elstner.   

Abstract

Glutamate-induced cell death of hippocampal HT22 cells is a model system for neuronal disorders due to depletion of glutathione levels and increase of intracellular reactive oxygen species. Standardized extracts of Hypericum perforatum (HPE) contain flavonoids known for antioxidative properties. In the above model, cytoprotective effects at a concentration of 0.05% HPE by attenuation of calcium fluxes and cellular energy statuses are reported.

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Year:  2007        PMID： 17346956     DOI： 10.1016/j.phymed.2007.02.001

Source DB:  PubMed          Journal:  Phytomedicine        ISSN： 0944-7113            Impact factor:   5.340


  12 in total

1.  Neuroprotective effects of high affinity Σ1 receptor selective compounds.

Authors:  Robert R Luedtke; Evelyn Perez; Shao-Hua Yang; Ran Liu; Suwanna Vangveravong; Zhude Tu; Robert H Mach; James W Simpkins
Journal:  Brain Res       Date:  2011-12-31       Impact factor: 3.252

2.  Hypericum Perforatum Hydroalcoholic Extract Mitigates Motor Dysfunction and is Neuroprotective in Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease.

Authors:  Zahra Kiasalari; Tourandokht Baluchnejadmojarad; Mehrdad Roghani
Journal:  Cell Mol Neurobiol       Date:  2015-06-29       Impact factor: 5.046

Review 3.  St. John's wort (Hypericum perforatum) and depression: what happens to the neurotransmitter systems?

Authors:  Gita Kholghi; Shirin Arjmandi-Rad; Mohammad-Reza Zarrindast; Salar Vaseghi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2022-03-16       Impact factor: 3.000

4.  Neuroprotective Effects of Kinetin Against Glutamate-Induced Oxidative Cytotoxicity in HT22 Cells: Involvement of Nrf2 and Heme Oxygenase-1.

Authors:  Yunpeng Wei; Dan Liu; Yin Zheng; Chaoshuang Hao; Honglian Li; Wuqing Ouyang
Journal:  Neurotox Res       Date:  2017-09-12       Impact factor: 3.911

5.  Alleviation by Hypericum perforatum of the stress-induced impairment of spatial working memory in rats.

Authors:  Emil Trofimiuk; Jan J Braszko
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2007-12-19       Impact factor: 3.000

6.  Antioxidant activity relationship of phenolic compounds in Hypericum perforatum L.

Authors:  Dejan Z Orčić; Neda M Mimica-Dukić; Marina M Francišković; Slobodan S Petrović; Emilija D Jovin
Journal:  Chem Cent J       Date:  2011-06-25       Impact factor: 4.215

7.  Dieckol Attenuates Microglia-mediated Neuronal Cell Death via ERK, Akt and NADPH Oxidase-mediated Pathways.

Authors:  Yanji Cui; Jee-Yun Park; Jinji Wu; Ji Hyung Lee; Yoon-Sil Yang; Moon-Seok Kang; Sung-Cherl Jung; Joo Min Park; Eun-Sook Yoo; Seong-Ho Kim; Sangmee Ahn Jo; Kyoungho Suk; Su-Yong Eun
Journal:  Korean J Physiol Pharmacol       Date:  2015-04-30       Impact factor: 2.016

8.  Neurotrophic, Cytoprotective, and Anti-inflammatory Effects of St. John's Wort Extract on Differentiated Mouse Hippocampal HT-22 Neurons.

Authors:  Gabriel A Bonaterra; Anna Schwendler; Julian Hüther; Hans Schwarzbach; Anja Schwarz; Christiane Kolb; Heba Abdel-Aziz; Ralf Kinscherf
Journal:  Front Pharmacol       Date:  2018-01-18       Impact factor: 5.810

Review 9.  Neuroprotective Activity of Hypericum perforatum and Its Major Components.

Authors:  Ana I Oliveira; Cláudia Pinho; Bruno Sarmento; Alberto C P Dias
Journal:  Front Plant Sci       Date:  2016-07-11       Impact factor: 5.753

Review 10.  Targeting Cellular Stress Mechanisms and Metabolic Homeostasis by Chinese Herbal Drugs for Neuroprotection.

Authors:  Hsiao-Chien Ting; Chia-Yu Chang; Kang-Yun Lu; Hong-Meng Chuang; Sheng-Feng Tsai; Mao-Hsuan Huang; Ching-Ann Liu; Shinn-Zong Lin; Horng-Jyh Harn
Journal:  Molecules       Date:  2018-01-28       Impact factor: 4.411
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