| Literature DB >> 17346815 |
Abstract
There is growing interest in the potential use of 5-HT(1A) receptor agonists as neuroprotective agents in stroke and traumatic brain injury. However, a new study using a recombinant 5-HT(1A) receptor cell line suggests that these agonists may promote as well as inhibit apoptotic responses. Because heterologously expressed receptors may couple promiscuously to inappropriate signal transduction pathways, the results should be interpreted with caution.Entities:
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Year: 2007 PMID： 17346815 PMCID： PMC1950678 DOI： 10.1016/j.bbamcr.2007.01.003
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002