Literature DB >> 17346672

Lateral diffusion of TGF-beta type I receptor studied by single-molecule imaging.

Xinyong Ma1, Qiang Wang, Yaxin Jiang, Zeyu Xiao, Xiaohong Fang, Ye-Guang Chen.   

Abstract

In this report, we investigated the lateral diffusion of transforming growth factor beta (TGF-beta) type I receptor (TbetaRI) in living cells by imaging and tracking individual green fluorescent protein tagged TbetaRI on the cell membrane. We found that when co-expressed with TGF-beta type II receptor (TbetaRII), the mobility of TbetaRI decreased significantly after TGF-beta1 stimulation. However, in the cells that had been depleted of cholesterol with Nystatin or methyl-beta-cyclodextrin, the diffusion rate of TbetaRI was not changed by TGF-beta1 treatment. Our observations suggest that membrane lipid-rafts provide an environment that facilitates the association of TbetaRI and TbetaRII for cell signaling.

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Year:  2007        PMID： 17346672     DOI： 10.1016/j.bbrc.2007.02.080

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  14 in total

1.  Cholesterol synthesis-related enzyme oxidosqualene cyclase is required to maintain self-renewal in primary erythroid progenitors.

Authors:  C Mejia-Pous; F Damiola; O Gandrillon
Journal:  Cell Prolif       Date:  2011-10       Impact factor: 6.831

2.  Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIalpha at the trans-Golgi network.

Authors:  Shane Minogue; K M Emily Chu; Emily J Westover; Douglas F Covey; J Justin Hsuan; Mark G Waugh
Journal:  J Lipid Res       Date:  2010-04-13       Impact factor: 5.922

3.  Biased μ-opioid receptor agonists diversely regulate lateral mobility and functional coupling of the receptor to its cognate G proteins.

Authors:  Barbora Melkes; Lucie Hejnova; Jiri Novotny
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2016-09-06       Impact factor: 3.000

4.  Lowering glycosphingolipid levels in CD4+ T cells attenuates T cell receptor signaling, cytokine production, and differentiation to the Th17 lineage.

Authors:  Yunxiang Zhu; Nathan Gumlaw; Jozsef Karman; Hongmei Zhao; Jinhua Zhang; Ji-Lei Jiang; Pete Maniatis; Andrea Edling; Wei-Lien Chuang; Craig Siegel; James A Shayman; Johanne Kaplan; Canwen Jiang; Seng H Cheng
Journal:  J Biol Chem       Date:  2011-03-14       Impact factor: 5.157

5.  Unveiling the mechanism of uptake and sub-cellular distribution of cerium oxide nanoparticles.

Authors:  Sanjay Singh; Amit Kumar; Ajay Karakoti; Sudipta Seal; William T Self
Journal:  Mol Biosyst       Date:  2010-08-09

6.  Rhomboid distorts lipids to break the viscosity-imposed speed limit of membrane diffusion.

Authors:  Alex J B Kreutzberger; Ming Ji; Siniša Urban; Jesse Aaron; Ljubica Mihaljević
Journal:  Science       Date:  2019-02-01       Impact factor: 47.728

7.  Specific activation of mitogen-activated protein kinase by transforming growth factor-beta receptors in lipid rafts is required for epithelial cell plasticity.

Authors:  Wei Zuo; Ye-Guang Chen
Journal:  Mol Biol Cell       Date:  2008-12-03       Impact factor: 4.138

8.  SMAD versus non-SMAD signaling is determined by lateral mobility of bone morphogenetic protein (BMP) receptors.

Authors:  Asja Guzman; Monika Zelman-Femiak; Jan H Boergermann; Sandra Paschkowsky; Peter A Kreuzaler; Peter Fratzl; Gregory S Harms; Petra Knaus
Journal:  J Biol Chem       Date:  2012-09-07       Impact factor: 5.157

9.  Regulation of TGF-β receptor activity.

Authors:  Fei Huang; Ye-Guang Chen
Journal:  Cell Biosci       Date:  2012-03-15       Impact factor: 7.133

Review 10.  Regulation of TGF-β Signal Transduction.

Authors:  Bing Zhao; Ye-Guang Chen
Journal:  Scientifica (Cairo)       Date:  2014-09-23
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