Literature DB >> 17345312

Biological active macrocyclic diterpenoids from chinese drug "Fáng Féng Cáo"; II. Derivatives of ovatodiolids and their cytotoxity.

M Arisawa1, M Nimura, A Fujita, T Hayashi, N Morita, S Koshimura.   

Abstract

Isolated macrocyclic diterpenoids, ovatodiolide ( 1), 4, 5-epoxyovatodiolide ( 2), anisomelic acid ( 3), 4, 7-oxycycloanisomelic acid ( 4), and 4-methylene-5-oxoanisomelic acid ( 6), from the Chinese crude drug "Fáng Féng Cáordquo;, and the derivatives of the isolated compounds were tested for their growth inhibiting activities in culture of KB cell line. Besides, the effects of 1 on Ehrlich carcinoma in mice are reported.

Entities:  

Year:  1986        PMID： 17345312     DOI： 10.1055/s-2007-969157

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  5 in total

1.  Antiproliferative property of n-hexane and chloroform extracts of Anisomeles malabarica (L). R. Br. in HPV16-positive human cervical cancer cells.

Authors:  Christo Paul Preethy; Ramamoorthy Padmapriya; Vaiyapuri Subbarayan Periasamy; Anvarbatcha Riyasdeen; Suresh Srinag; Hanumanthappa Krishnamurthy; Ali Abdullah Alshatwi; Mohammad Abdulkader Akbarsha
Journal:  J Pharmacol Pharmacother       Date:  2012-01

2.  Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica.

Authors:  Christo Paul Preethy; Ali Abdullah Alshatwi; Muthukumaran Gunasekaran; Mohammad Abdulkadher Akbarsha
Journal:  Sci Pharm       Date:  2013-01-25

3.  Ovatodiolide of Anisomeles indica Exerts the Anticancer Potential on Pancreatic Cancer Cell Lines through STAT3 and NF-κB Regulation.

Authors:  Ya-Ju Hsieh; Sung-Pin Tseng; Yu-Hsuan Kuo; Tain-Lu Cheng; Chiao-Yu Chiang; Yew-Min Tzeng; Wan-Chi Tsai
Journal:  Evid Based Complement Alternat Med       Date:  2016-05-08       Impact factor: 2.629

4.  Ovatodiolide Targets β -Catenin Signaling in Suppressing Tumorigenesis and Overcoming Drug Resistance in Renal Cell Carcinoma.

Authors:  Jar-Yi Ho; Ren-Jun Hsu; Chieh-Lin Wu; Wen-Liang Chang; Tai-Lung Cha; Dah-Shyong Yu; Cheng-Ping Yu
Journal:  Evid Based Complement Alternat Med       Date:  2013-05-26       Impact factor: 2.629

5.  Ovatodiolide Inhibits Breast Cancer Stem/Progenitor Cells through SMURF2-Mediated Downregulation of Hsp27.

Authors:  Kuan-Ta Lu; Bing-Yen Wang; Wan-Yu Chi; Ju Chang-Chien; Jiann-Jou Yang; Hsueh-Te Lee; Yew-Min Tzeng; Wen-Wei Chang
Journal:  Toxins (Basel)       Date:  2016-04-28       Impact factor: 4.546
  5 in total

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