Literature DB >> 17344566

Simvastatin-induced bilateral leg compartment syndrome and myonecrosis associated with hypothyroidism.

Michael J Ramdass1, Gurpreet Singh, Brian Andrews.   

Abstract

A 54-year-old hypothyroid male taking thyroxine and simvastatin presented with bilateral leg compartment syndrome and myonecrosis. Urgent fasciotomies were performed and the patient made an uneventful recovery with the withdrawal of simvastatin. It is likely that this complication will be seen more often with the increased worldwide use of this drug and its approval for all arteriopathic patients.

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Year:  2007        PMID： 17344566      PMCID： PMC2599992          DOI： 10.1136/pgmj.2006.051334

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN： 0032-5473            Impact factor:   2.401


  5 in total

1.  Hypothyroidism and simvastatin.

Authors:  B Tomlinson; W Lan
Journal:  Hong Kong Med J       Date:  2001-06       Impact factor: 2.227

2.  Judicious evaluation of adverse drug reactions: inaccurate assessment of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced muscle injury.

Authors:  B L Dietz; K C Oberg
Journal:  Pharmacotherapy       Date:  1999-02       Impact factor: 4.705

3.  [Rhabdomyolysis as a side effect of simvastatin treatment].

Authors:  Bosiljka Iskra; Marijana Zivko; Petar Kes
Journal:  Acta Med Croatica       Date:  2005

4.  Hypothyroidism presenting as hypercholesterolaemia and simvastatin-induced myositis.

Authors:  Y T Hung; V T Yeung
Journal:  Hong Kong Med J       Date:  2000-12       Impact factor: 2.227

5.  Rhabdomyolysis and compartment syndrome with coadministration of risperidone and simvastatin.

Authors:  Michael A Webber; Waqar Mahmud; Jeffery D Lightfoot; Anantha Shekhar
Journal:  J Psychopharmacol       Date:  2004-09       Impact factor: 4.153
  5 in total
  9 in total

1.  Spontaneous bilateral compartment syndrome of the legs: A case report and review of the literature.

Authors:  T Khan; G H Lee; A Alvand; J S Mahaluxmivala
Journal:  Int J Surg Case Rep       Date:  2012-02-20

2.  Bilateral gluteal compartment syndrome following right total knee revision: a case report.

Authors:  Kristie D Osteen; Shireen H Haque
Journal:  Ochsner J       Date:  2012

3.  Surgical treatment for muscle injuries.

Authors:  Leonardo Addêo Ramos; Rogério Teixeira de Carvalho; Rene Jorge Abdalla; Sheila Jean McNeill Ingham
Journal:  Curr Rev Musculoskelet Med       Date:  2015-06

Review 4.  Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism.

Authors:  Beatrice A Golomb; Marcella A Evans
Journal:  Am J Cardiovasc Drugs       Date:  2008       Impact factor: 3.571

5.  Statin-induced bilateral foot drop in a case of hypothyroidism.

Authors:  Neera Chaudhary; Ashish Kumar Duggal; Prashant Makhija; Vinod Puri; Geeta Anjum Khwaja
Journal:  Ann Indian Acad Neurol       Date:  2015 Jul-Sep       Impact factor: 1.383

6.  Gluteal Compartment Syndrome following an Iliac Bone Marrow Aspiration.

Authors:  Edmundo Berumen-Nafarrate; Carlos Vega-Najera; Carlos Leal-Contreras; Irene Leal-Berumen
Journal:  Case Rep Orthop       Date:  2013-12-11

7.  Hypothyroid-induced acute compartment syndrome in all extremities.

Authors:  Matthew C Musielak; Jung Hee Chae
Journal:  J Surg Case Rep       Date:  2016-12-20

Review 8.  Atraumatic Bilateral Acute Compartment Syndrome of the Lower Legs: A Review of the Literature.

Authors:  Madeline Warren; Govind Dhillon; Joseph Muscat; Ali Abdulkarim
Journal:  Cureus       Date:  2021-12-08

9.  Gluteal Compartment Syndrome Secondary to Pelvic Trauma.

Authors:  Fernando Diaz Dilernia; Ezequiel E Zaidenberg; Sebastian Gamsie; Danilo E R Taype Zamboni; Guido S Carabelli; Jorge D Barla; Carlos F Sancineto
Journal:  Case Rep Orthop       Date:  2016-08-08
  9 in total

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