BACKGROUND: Nutrients in dietary fruit and vegetables have been hypothesized to lower the risk of glioma by reducing the endogenous formation of N-nitroso compounds. Studies examining fruit and vegetable consumption and brain tumors have relied on case-control study designs, with one exception, and results have been inconsistent. OBJECTIVE: We prospectively examined the relation between consumption of fruit and vegetables (and specifically carotenoids) and the risk of glioma among men and women in 3 large US cohort studies: the Health Professionals Follow-Up Study (HPFS), the Nurses' Health Study I (NHS I), and NHS II. DESIGN: Dietary intake was assessed by food-frequency questionnaires obtained at baseline and updated every 4 y through 2002 (HPFS and NHS I) or 2003 (NHS II). We identified 296 incident adult gliomas during 3 669 589 person-years of follow-up. Cox proportional hazard models were used to estimate incidence rate ratios (RR) and 95% CIs between intake of fruit, vegetables, and carotenoids and glioma risk, with adjustment for age and total caloric intake. RESULTS: Updated average consumption of total fruit and vegetables was not significantly associated with glioma risk in the men and women (pooled multivariate RR in a comparison of the highest with the lowest quintile: 1.12; 95% CI: 0.74, 1.69). Other fruit and vegetable subgroups, individual fruit and vegetables, and 5 major carotenoids were not significantly associated with risk of glioma. CONCLUSION: Our findings suggest that fruit, vegetable, and carotenoid consumption is not likely associated strongly with the risk of adult glioma.
BACKGROUND: Nutrients in dietary fruit and vegetables have been hypothesized to lower the risk of glioma by reducing the endogenous formation of N-nitroso compounds. Studies examining fruit and vegetable consumption and brain tumors have relied on case-control study designs, with one exception, and results have been inconsistent. OBJECTIVE: We prospectively examined the relation between consumption of fruit and vegetables (and specifically carotenoids) and the risk of glioma among men and women in 3 large US cohort studies: the Health Professionals Follow-Up Study (HPFS), the Nurses' Health Study I (NHS I), and NHS II. DESIGN: Dietary intake was assessed by food-frequency questionnaires obtained at baseline and updated every 4 y through 2002 (HPFS and NHS I) or 2003 (NHS II). We identified 296 incident adult gliomas during 3 669 589 person-years of follow-up. Cox proportional hazard models were used to estimate incidence rate ratios (RR) and 95% CIs between intake of fruit, vegetables, and carotenoids and glioma risk, with adjustment for age and total caloric intake. RESULTS: Updated average consumption of total fruit and vegetables was not significantly associated with glioma risk in the men and women (pooled multivariate RR in a comparison of the highest with the lowest quintile: 1.12; 95% CI: 0.74, 1.69). Other fruit and vegetable subgroups, individual fruit and vegetables, and 5 major carotenoids were not significantly associated with risk of glioma. CONCLUSION: Our findings suggest that fruit, vegetable, and carotenoid consumption is not likely associated strongly with the risk of adult glioma.
Authors: Robert Dubrow; Amy S Darefsky; Yikyung Park; Susan T Mayne; Steven C Moore; Briseis Kilfoy; Amanda J Cross; Rashmi Sinha; Albert R Hollenbeck; Arthur Schatzkin; Mary H Ward Journal: Cancer Epidemiol Biomarkers Prev Date: 2010-06-22 Impact factor: 4.254
Authors: David J Cote; Alaina M Bever; Yu-Han Chiu; Helena Sandoval-Insausti; Stephanie A Smith-Warner; Jorge E Chavarro; Meir J Stampfer Journal: Am J Epidemiol Date: 2022-03-24 Impact factor: 5.363
Authors: Haitao Luo; Gary O Rankin; Lingzhi Liu; Matthew K Daddysman; Bing-Hua Jiang; Yi Charlie Chen Journal: Nutr Cancer Date: 2009 Impact factor: 2.900
Authors: Mary Beth Terry; Geoffrey Howe; Janice M Pogoda; Fang Fang Zhang; Anders Ahlbom; Won Choi; Graham G Giles; Julian Little; Flora Lubin; Francoise Menegoz; Philip Ryan; Brigitte Schlehofer; Susan Preston-Martin Journal: Ann Epidemiol Date: 2009-03 Impact factor: 3.797
Authors: Gabriella M Anic; Melissa H Madden; Kelly Sincich; Reid C Thompson; L Burton Nabors; Jeffrey J Olson; Renato V LaRocca; James E Browning; Edward Pan; Kathleen M Egan Journal: Eur J Epidemiol Date: 2013-05-17 Impact factor: 8.082
Authors: Dominique S Michaud; Crystal N Holick; Tracy T Batchelor; Edward Giovannucci; David J Hunter Journal: Am J Clin Nutr Date: 2009-07-08 Impact factor: 7.045
Authors: Adina R Lemeshow; Eric B Rimm; Deborah S Hasin; Ashley N Gearhardt; Alan J Flint; Alison E Field; Jeanine M Genkinger Journal: Appetite Date: 2017-11-01 Impact factor: 3.868
Authors: Jianchu Chen; Zhaoliang Li; Allen Y Chen; Xingqian Ye; Haitao Luo; Gary O Rankin; Yi Charlie Chen Journal: Int J Mol Sci Date: 2013-03-15 Impact factor: 5.923